21977-88-8

Basic information

• Product Name: 4H-1,3-Thiazine, 5,6-dihydro-2-(4-nitrophenyl)-
• CAS NO: 21977-88-8
• Molecular Formula: C10H10N2O2S
• Molecular Weight: 222.268
• Mol File: 21977-88-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4H-1,3-Thiazine, 5,6-dihydro-2-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,3-Thiazine, 5,6-dihydro-2-(4-nitrophenyl)-(21977-88-8)
• EPA Substance Registry System: 4H-1,3-Thiazine, 5,6-dihydro-2-(4-nitrophenyl)-(21977-88-8)

Safety Data

• Hazardous Substances Data: 21977-88-8(Hazardous Substances Data)

Upstream product

• 158392-26-8 N-(3-bromopropyl)-p-nitrobenzamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 90690-76-9 N-(3-Hydroxy-propyl)-4-nitro-benzamid 

Downstream Products

• 50708-33-3 N-[6-(4-nitro-phenyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-7-yl]-2-phenoxy-acetamide 
• 50708-34-4 N-[6-(4-amino-phenyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-7-yl]-2-phenoxy-acetamide 
• 50886-14-1 [6-(4-nitro-phenyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-7-yl]-carbamic acid benzyl ester 
• 58134-48-8 [6-(4-nitro-phenyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-7-yl]-carbamic acid tert-butyl ester 
• 61298-44-0 N-[6-(4-nitro-phenyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-7-yl]-phthalimide 

Relevant articles and documents

Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines

An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -1,3-thiazines is developed via microwave-assisted ring closure of ω-thioamidoalcohols promoted by ethyl polyphosphate (PPE). The cyclization reaction involves an S N 2-type mechanism and features the advantages of very short reaction times, high yields and a predictable stereochemical outcome. The acyclic precursors are prepared in high overall yields by an improved diacylation-thionation-saponification sequence from commercially available ω-amino alcohols. The whole process is metal-free and operationally simple.