219783-86-5

Upstream product

• 109-01-3 1-methyl-piperazine 
• 219783-81-0 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-8-methyl-4-[[(trifluoromethyl)sulphonyl]oxy]-2H-1-benzopyran-2-one 
• 219783-80-9 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-8-methyl-2H-1-benzopyran-2-one 

Relevant academic research and scientific papers

Fine tuning of physico-chemical parameters to optimise a new series of novobiocin analogues

A novel series of novobiocin analogues has been synthesised by removing the lipophilic aryl chain in novobiocin and introducing an amino substituent. The structural modifications have been dictated by the control of lipophilicity and the dissociation constant of the resulting compounds. Antibacterial activity of the new coumarin derivatives could be correlated with the amount of uncharged form in physiological conditions.

Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments

A subject of the invention is the compounds of formula (I): STR1 having antibiotic properties.