219783-80-9

Upstream product

• 67973-49-3 4,7-dihydroxy-8-methyl-2H-1-benzopyran-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 265325-01-7 carbonic acid benzyl ester 7-(tert-butyl-diphenyl-silanyloxy)-8-methyl-2-oxo-2H-chromen-4-yl ester 
• 251354-71-9 4-(2-bromo-ethoxy)-7-(tert-butyl-diphenyl-silanyloxy)-8-methyl-chromen-2-one 
• 219783-81-0 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-8-methyl-4-[[(trifluoromethyl)sulphonyl]oxy]-2H-1-benzopyran-2-one 
• 265325-08-4 5-Methyl-1H-pyrrole-2-carboxylic acid (2S,3R,4S,5S,6S)-2-[3-benzyloxycarbonyl-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromen-7-yloxy]-3-hydroxy-5-methoxy-6-methyl-tetrahydro-pyran-4-yl ester 
• 265325-03-9 7-(tert-butyl-diphenyl-silanyloxy)-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromene-3-carboxylic acid benzyl ester 
• 265325-02-8 7-(tert-butyl-diphenyl-silanyloxy)-4-hydroxy-8-methyl-2-oxo-2H-chromene-3-carboxylic acid benzyl ester 
• 265325-05-1 7-hydroxy-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromene-3-carboxylic acid benzyl ester 
• 251354-74-2 4-(2-Bromo-ethoxy)-3-chloro-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-pyran-2-yloxy)-8-methyl-chromen-2-one 
• 251354-73-1 4-(2-Bromo-ethoxy)-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-pyran-2-yloxy)-8-methyl-chromen-2-one 
• 251354-72-0 4-(2-bromo-ethoxy)-7-hydroxy-8-methyl-chromen-2-one 
• 219783-86-5 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-8-methyl-4-(4-methyl-1-piperazinyl)-2H-1-benzopyran-2-one 

Relevant academic research and scientific papers

Tosylates in palladium-catalysed coupling reactions. Application to the synthesis of arylcoumarin inhibitors of gyrase B

The palladium-catalysed coupling reaction between tosylate derivatives and organostannanes has been investigated as a methodology for carbon-carbon bond formation. Aryl substituents have been successfully incorporated even in highly functionalised coumarin structures to afford new analogues of the antibiotic novobiocin. (C) 2000 Elsevier Science Ltd.

Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.

Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments

A subject of the invention is the compounds of formula (I): STR1 having antibiotic properties.