219783-80-9

Upstream product

• 67973-49-3 4,7-dihydroxy-8-methyl-2H-1-benzopyran-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 251354-71-9 4-(2-bromo-ethoxy)-7-(tert-butyl-diphenyl-silanyloxy)-8-methyl-chromen-2-one 
• 219783-81-0 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-8-methyl-4-[[(trifluoromethyl)sulphonyl]oxy]-2H-1-benzopyran-2-one 
• 265325-08-4 5-Methyl-1H-pyrrole-2-carboxylic acid (2S,3R,4S,5S,6S)-2-[3-benzyloxycarbonyl-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromen-7-yloxy]-3-hydroxy-5-methoxy-6-methyl-tetrahydro-pyran-4-yl ester 
• 265325-03-9 7-(tert-butyl-diphenyl-silanyloxy)-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromene-3-carboxylic acid benzyl ester 
• 265325-02-8 7-(tert-butyl-diphenyl-silanyloxy)-4-hydroxy-8-methyl-2-oxo-2H-chromene-3-carboxylic acid benzyl ester 
• 265325-05-1 7-hydroxy-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromene-3-carboxylic acid benzyl ester 
• 219783-86-5 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-8-methyl-4-(4-methyl-1-piperazinyl)-2H-1-benzopyran-2-one 
• 265325-01-7 carbonic acid benzyl ester 7-(tert-butyl-diphenyl-silanyloxy)-8-methyl-2-oxo-2H-chromen-4-yl ester 
• 251354-74-2 4-(2-Bromo-ethoxy)-3-chloro-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-pyran-2-yloxy)-8-methyl-chromen-2-one 
• 251354-73-1 4-(2-Bromo-ethoxy)-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-pyran-2-yloxy)-8-methyl-chromen-2-one 
• 251354-72-0 4-(2-bromo-ethoxy)-7-hydroxy-8-methyl-chromen-2-one 

Relevant academic research and scientific papers

Tosylates in palladium-catalysed coupling reactions. Application to the synthesis of arylcoumarin inhibitors of gyrase B

The palladium-catalysed coupling reaction between tosylate derivatives and organostannanes has been investigated as a methodology for carbon-carbon bond formation. Aryl substituents have been successfully incorporated even in highly functionalised coumarin structures to afford new analogues of the antibiotic novobiocin. (C) 2000 Elsevier Science Ltd.

Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments

A subject of the invention is the compounds of formula (I): STR1 having antibiotic properties.

Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.