219786-86-4

Upstream product

• 591-50-4 iodobenzene 
• 4685-10-3 3-(methoxycarbonyl)-1-methylpyridinium iodide 
• 4124-31-6 trichloroacetic acid anhydride 

Downstream Products

• 56820-34-9 dimethyl 1-methyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate 

Relevant academic research and scientific papers

Synthesis of 4-functionalized aryl-3,5-diacyl-1,4-dihydropyridines

The valuable N-unsubstituted 4-aryl-3,5-diacyl-1,4-dihydropyridines 12b-f, bearing an electron-withdrawing substituent at the benzene ring, have been synthesized by the copper-mediated addition of functionalized arylmagnesium reagents 2b-f to N-benzhydrylpyridinium salt 9, followed by acylation with trichloroacetic anhydride and the subsequent haloform reaction and N-deprotection.

Synthesis of 3-5-diacyl-4-phenyl-1,4-dihydropyridines

3,5-Diacyl-4-phenyl-1,4-dihydropyridines have been synthesized via a regio- and chemoselective addition of Ph2Cu(CN)Li2 to β-substituted N- alkylpyridinium salts, followed by acylation of the intermediate 1,4- dihydropyridines with t