219794-74-8

Basic information

• Product Name: [(2R,4S,5S)-5-ethynyl-1-azabicyclo[2.2.2]oct-2-yl]methanol
• Synonyms: [(2R,4S,5S)-5-Ethynyl-1-azabicyclo[2.2.2]oct-2-yl]methanol
• CAS NO: 219794-74-8
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.2322
• Mol File: 219794-74-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 250.247°C at 760 mmHg
• Flash Point: 110.175°C
• Density: 1.121g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: [(2R,4S,5S)-5-ethynyl-1-azabicyclo[2.2.2]oct-2-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R,4S,5S)-5-ethynyl-1-azabicyclo[2.2.2]oct-2-yl]methanol(219794-74-8)
• EPA Substance Registry System: [(2R,4S,5S)-5-ethynyl-1-azabicyclo[2.2.2]oct-2-yl]methanol(219794-74-8)

Safety Data

• Hazardous Substances Data: 219794-74-8(Hazardous Substances Data)

Upstream product

• 207129-35-9 [(2R,4S,5R)-2-hydroxymethyl-5-vinyl-2-quinuclidine] 

Downstream Products

• 1185735-37-8 6-((1'S,2'R,4'S,5'S)-2'-hydroxymethyl-1'-azabicyclo[2.2.2]oct-5'-yl)-4-phenyl-(Z)-3-hexen-5-yn-2-one 
• 1185735-36-7 6-((1'S,2'R,4'S,5'S)-2'-hydroxymethyl-1'-azabicyclo[2.2.2]oct-5'-yl)-4-phenyl-(E)-3-hexen-5-yn-2-one 
• 1185735-34-5 5-((1'S,2'R,4'S,5'S)-2'-hydroxymethyl-1'-azabicyclo[2.2.2]oct-5'-yl)-3-methyl-(E)-2-penten-4-ynoic acid ethyl ester 
• 1185735-35-6 5-((1'S,2'R,4'S,5'S)-2'-hydroxymethyl-1'-azabicyclo[2.2.2]oct-5'-yl)-3-phenyl-(E)-2-penten-4-ynoic acid methyl ester 

Relevant articles and documents

Synthesis of new quinuclidine derivatives via Pd-mediated cross-coupling and cross-benzannulation reactions

New functionalized quinuclidines were prepared via palladium-catalyzed addition reactions of terminal alkynes (donors) to internal alkynes (acceptors). The enantiopure terminal alkynes were derivatives of quincoridine and quincorine, two semi-natural Cinc

Cross-coupling reactions in Cinchona alkaloid chemistry: Aryl-substituted and dimeric quinine, quinidine, as well as quincorine and quincoridine derivatives

Cross-coupling reactions of modified Cinchona alkaloids provide access to a wide variety of novel arylated and dimeric derivatives of quinine and quinidine containing a single and double 1,2-amino alcohol functionality. Sonogashira and Heck reactions allow functionalization of ethynyl and 11-iodovinyl precursors. The role of bystander functionality is investigated.