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12-chloro-5,10-dihydro-11H-5,10-methanodibenzo[a,d][7]annulen-11-one is a complex organic chemical compound with the molecular formula C16H15ClO. It belongs to the class of dibenzo[a,d][7]annulenes, which are a group of polycyclic aromatic hydrocarbons. This specific compound features a chlorine atom at the 12th position, a methyl group bridging the 5th and 10th carbons, and a ketone functional group at the 11th position. It is a colorless solid with potential applications in the synthesis of pharmaceuticals and other organic compounds. Due to its complex structure and specific functional groups, it is important to handle 12-chloro-5,10-dihydro-11H-5,10-methanodibenzo[a,d][7]annulen-11-one with care, as it may have potential health and environmental impacts.

2198-01-8

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2198-01-8 Usage

Chemical class

Steroids

Type

Synthetic steroid

Common uses

Research and laboratory studies

Target enzyme

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

Therapeutic potential

Treatment of metabolic disorders (e.g. diabetes and obesity)

Other potential properties

Anti-inflammatory and anti-cancer

Chemical structure

12-chloro group attached to a 5,10-dihydro-11H-5,10-methanodibenzo[a,d][7]annulen-11-one scaffold

Value in research

Understanding biological pathways and pharmacological actions of steroids

Check Digit Verification of cas no

The CAS Registry Mumber 2198-01-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,9 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2198-01:
(6*2)+(5*1)+(4*9)+(3*8)+(2*0)+(1*1)=78
78 % 10 = 8
So 2198-01-8 is a valid CAS Registry Number.

2198-01-8Downstream Products

2198-01-8Relevant academic research and scientific papers

ACETOLYSES OF 1-SUBSTITUTED TRANS-7,8-DICHLORODIBENZOBICYCLO OCTADIENES.

Elnagar, H.Y.,Chow, K.H.,Johnson, A.T.,Somanathan, R.,Nunez, P.,et al.

, p. 5841 - 5848 (2007/10/02)

The preparations and silver-assisted acetolyses of the 1-methoxy (5), 1-methyl (6), 1-carbomethoxy (7), and 1-nitro (8) derivatives of trans-7,8-dichlorodibenzobicyclo octa-2,5-dienes are described.Rearranged products possessing the dibenzobicyclo octadiene skeleton were identified.With compound 5, the P8:P7 ratio (ratio of products derived from ionizations of C8-Cl and C7-Cl bonds) was 1.3.For 6 and 7, the corresponding P8:P7 ratios were 0.4 and 33 respectively.Acetolysis of 8 led to products in detectable quantities from ionization of the C8-Cl bond only.The data support the proposal by Cristol that the transition states for these solvolytic rearrangements more closely resemble phenonium ion-like intermediates than benzyl cations.

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