219814-65-0Relevant articles and documents
Chemoenzymatic synthesis of an N-acetylneuraminic acid analogue having a carbamoylmethyl group at C-4 as an inhibitor of sialidase from influenza virus
Ikeda, Kiyoshi,Kimura, Fuyuki,Sano, Kimihiko,Suzuki, Yasuo,Achiwa, Kazuo
, p. 183 - 189 (2007/10/03)
5,9-Diacetamido-2,6-anhydro-O-4-carbamoylmethyl-3,5,9-trideoxy-d-glycero-d-galacto-non-2-enonic acid (1) was synthesized via a key intermediate 2 through the Neu5Ac aldolase [E.C.4.1.3.3]-catalyzed aldol reaction of 2-acetamido-2,6-dideoxy-6-azido-d-glucose with sodium pyruvate operating under alkaline conditions (pH 10.5) in order to accelerate epimerization C-2 of N-acetyl-d-glucosamine (d-GlcNAc) derivatives. Compound 1 showed inhibitory activity against sialidase. Copyright (C) 1998 Elsevier Science Ltd.