219823-49-1 Usage
General Description
2-amino-4,5-difluoro-benzonitrile (CAS number 497079-04-2) is a chemical compound with the molecular formula C7H4F2N2. It is an aromatic cyano compound with two fluorine atoms attached to the benzene ring and an amino group attached at the 2-position. This chemical is often used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the preparation of various organic compounds, such as dyes and fluorescent materials. Additionally, the difluoro-benzonitrile group has been studied for its potential applications in materials science and as a building block for designing novel molecular structures with specific properties. However, it is important to handle this chemical with care, as it may be harmful if ingested, inhaled, or absorbed through the skin, and it may cause irritation to the eyes, skin, and respiratory system.
Check Digit Verification of cas no
The CAS Registry Mumber 219823-49-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,8,2 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 219823-49:
(8*2)+(7*1)+(6*9)+(5*8)+(4*2)+(3*3)+(2*4)+(1*9)=151
151 % 10 = 1
So 219823-49-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F2N2/c8-5-1-4(3-10)7(11)2-6(5)9/h1-2H,11H2
219823-49-1Relevant articles and documents
ARYLCARBOXAMIDES AND USES THEREOF
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Paragraph 0233, (2017/12/13)
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic diseases such as scleroderma; lung disease, such as pulmonary fibrosis including idiopathic pulmonary fibrosis (IPF); heart disease, such as heart failure due to ischaemic heart disease, valvular heart disease and hypertensive heart disease, diabetic cardiomyopathy and hypertension; liver disease, such as cirrhosis of the liver; and kidney disease, such as progressive kidney disease glomerulonephritis and diabetic nephropathy; and eye disease such as diabetic retinopathy; skin or subcutaneous scarring, such as keloids, adhesions, hypertrophic scarring or cosmetic scarring; or as an adjuvant or anti-fibrotic in pancreatic cancer to increase chemotherapeutic drug penetration by reducing the density of the connective tissue stroma.
HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
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Page/Page column 55, (2010/06/11)
The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
