219834-95-4

Basic information

• Product Name: 4-METHOXYNAPHTHALENE-1-BORONIC ACID
• Synonyms: (4-methoxy-1-naphthyl)boronic acid(SALTDATA: FREE);(4-methoxy-1-naphthyl)boronic acid;8-Methoxyquinoline-5-boronic acid;AKOS BRN-0350;4-METHOXYNAPHTHALENE-1-BORONIC ACID;4-Methoxynaphthalen-1-ylboronic acid
• CAS NO: 219834-95-4
• Molecular Formula: C₁₁H₁₁BO₃
• Molecular Weight: 202.01
• Product Categories: Aryl Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Monosubstituted Aryl Boronic Acids;Organometallic Reagents
• Mol File: 219834-95-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 195 °C
• Boiling Point: 413.8°Cat760mmHg
• Flash Point: 204.1°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 1.37E-07mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.35±0.30(Predicted)
• CAS DataBase Reference: 4-METHOXYNAPHTHALENE-1-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYNAPHTHALENE-1-BORONIC ACID(219834-95-4)
• EPA Substance Registry System: 4-METHOXYNAPHTHALENE-1-BORONIC ACID(219834-95-4)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 219834-95-4(Hazardous Substances Data)

Usage

General Description

4-Methoxynaphthalene-1-boronic acid is a chemical compound with the formula C12H11BO3. It is commonly used as a building block in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and materials. 4-METHOXYNAPHTHALENE-1-BORONIC ACID is a boronic acid derivative of naphthalene, with a methoxy group attached to the aromatic ring. It is soluble in organic solvents and is stable under standard laboratory conditions. Its unique structure and reactivity make it an important intermediate in the production of various compounds for use in the pharmaceutical and chemical industries.

InChI:InChI=1/C11H11BO3/c1-15-11-7-6-10(12(13)14)8-4-2-3-5-9(8)11/h2-7,13-14H,1H3

Upstream product

• 688-74-4 boric acid tributyl ester 
• 7732-18-5 water 
• 5419-55-6 Triisopropyl borate 
• 5467-58-3 1-bromo-4-methoxynaphthalene 
• 2216-69-5 1-Methoxynaphthalene 
• 121-43-7 Trimethyl borate 

Relevant articles and documents

Electrochemical Synthesis of Biaryls via Oxidative Intramolecular Coupling of Tetra(hetero)arylborates

We report herein versatile, transition metal-free and additive-free (hetero)aryl-aryl coupling reactions promoted by the oxidative electrocoupling of unsymmetrical tetra(hetero)arylborates (TABs) prepared from ligand-exchange reactions on potassium trifluoroarylborates. Exploiting the power of electrochemical oxidations, this method complements the existing organoboron toolbox. We demonstrate the broad scope, scalability, and robustness of this unconventional catalyst-free transformation, leading to functionalized biaryls and ultimately furnishing drug-like small molecules, as well as late stage derivatization of natural compounds. In addition, the observed selectivity of the oxidative coupling reaction is related to the electronic structure of the TABs through quantum-chemical calculations and experimental investigations.

CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA]

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1'), (100), (100'), (200) and (200') and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.