219859-71-9Relevant academic research and scientific papers
Reactivity and regiochemical behavior of the 2,2-difluorocyclopropylcarbinyl cation: A new and improved mechanistic probe to distinguish radical and carbocation intermediates
Tian, Feng,Battiste, Merle A.,Dolbier Jr., William R.
, p. 193 - 195 (1999)
(equation presented) Acetolysis of 2,2-difluorocyclopropylcarbinyl tosylate (5) yields products derived from both SN1 and SN2 processes. Product identification and kinetic data indicated, as had been predicted computationally, that t
NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVE AND A PRODUCTION METHOD FOR SAME
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Paragraph 0476; 0477; 0478, (2014/12/09)
The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).
NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVES AND METHOD FOR PREPARING THE SAME
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Paragraph 0495; 0496; 0497, (2014/09/16)
The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).
New azetidine derivatives, pharmaceutical compositions and uses thereof
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Paragraph 0462; 0463; 0464; 0465, (2013/07/19)
The invention relates to new azetidine derivatives of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
NEW AZETIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Page/Page column 81; 82, (2013/07/19)
The invention relates to new azetidine derivatives of the formula (I), to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Reactivity and regiochemical behavior in the solvolysis reactions of (2,2-difluorocyclopyl)methyl tosylates
Battiste, Merle A.,Tian, Feng,Baker, John M.,Bautista, Olivia,Villalobos, Janette,Dolbier Jr., William R.
, p. 39 - 51 (2007/10/03)
The rate constants for acetolysis of (2,2-difluorocyclopropyl)methyl tosylate, and (2,2-difluoro-3-methylcyclopropyl)methyl tosylate at 92°C and of 1-(2,2-difluoropropyl)ethyl tosylate at 42°C are reported and the rectivities and regiochemistries of ring opening of these systems are discussed and compared with expectations based on computational results. The results are discussed in terms of the use of (2,2-difluorocyclopropyl)methyl systems as mechanistic probes.
