509072-57-5

Basic information

• Product Name: 2,2-DIFLUOROCYCLOPROPYLMETHANOL
• Synonyms: 2,2-DIFLUOROCYCLOPROPYLMETHANOL;2,2-Difluorocyclopropanemethan;2,2-Difluorocyclopropanemethanol, 97%;2,2-Difluorocyclopropylcarbinol;(2,2-Difluorocyclopropyl)-Methanol, 97+%;(2,2-Difluorocyclopropyl);Cyclopropanemethanol, 2,2-difluoro-
• CAS NO: 509072-57-5
• Molecular Formula: C₄H₆F₂O
• Molecular Weight: 108.09
• Mol File: 509072-57-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 129°C
• Flash Point: 16.4 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 17.8mmHg at 25°C
• Refractive Index: 1.392
• PKA: 15.10±0.10(Predicted)
• CAS DataBase Reference: 2,2-DIFLUOROCYCLOPROPYLMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUOROCYCLOPROPYLMETHANOL(509072-57-5)
• EPA Substance Registry System: 2,2-DIFLUOROCYCLOPROPYLMETHANOL(509072-57-5)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN1987
• HazardClass: IRRITANT
• Hazardous Substances Data: 509072-57-5(Hazardous Substances Data)

Usage

Uses

2,2-Difluorocyclopropanemethanol is used as an intermediate in the preparation of (2,2-difluorocyclopropyl)methylamine. It is also used as a reagent in the synthesis of pyrrolopyridine derivatives, which finds application as an antiviral agent.

InChI:InChI=1/C4H6F2O/c5-4(6)1-3(4)2-7/h3,7H,1-2H2

Upstream product

• 107873-03-0 2,2-difluorocyclopropane-1-carboxylic acid 
• 509072-58-6 (2,2-difluorocyclopropyl)methyl p-nitrobenzoate 

Downstream Products

• 219859-71-9 (2,2-difluorocyclopropyl)methyl 4-methylbenzenesulfonate 
• 1393469-61-8 (2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate 
• 1446020-95-6 N-((1S)-1-(4-(1-(2-((2,2-difluorocyclopropyl)methoxy)-3-fluoropyridin-4-yl)azetidin-3-yl)phenyl)ethyl)acetamide 
• 1446021-00-6 C₂₁H₂₃F₃N₄O₂ 
• 1192109-69-5 2,2-difluorocyclopropane-1-carbaldehyde 
• 233584-55-9 (2,2-difluorocyclopropyl)methyl acetate 

Relevant articles and documents

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds. In addition, comparison with relevant linear chain derivatives is provided, as well as lipophilicity changes occurring upon chain extension of acyclic precursors to give cyclopropyl containing compounds. For the compounds investigated, fluorination of the isopropyl substituent led to larger lipophilicity modulation compared to fluorination of the cyclopropyl substituent.

COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

OXAZOLIDINONE HYDROXAMIC ACID COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

This invention pertains generally to treating bacterial infections using organic compounds of Formula I. In certain aspects, the invention pertains to treating infections caused by Gram-negative bacteria. (I) wherein X, Y, R1, R2, R3, R4 and R5 and defined herein.