219865-88-0Relevant academic research and scientific papers
COMPOUNDS FOR THE TREATMENT OF ONCOVIRUS INDUCED CANCER AND METHODS OF USE THEREOF
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Page/Page column 89; 93-94; 116, (2020/10/21)
The pesent invention relates to compounds of formula (I) pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof and their use for the prevention and treatment of oncovirus induced cancer in a subject.
INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS
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Page/Page column 97; 101; 108-109, (2020/10/21)
The present invention relates to new inhibitors of Notch signalling pathway and its use in the treatment and/or prevention of cancers.
Kinetics of the reaction of 2-chloro-3-nitro- and 2-chloro-5-nitropyridines with aryloxide ions in methanol
El-Bardan, Ali A.
, p. 347 - 353 (2007/10/03)
The kinetics of the reaction of 2-chloro-3-nitropyridine (ortho-like) and 2-chloro-5-nitropyridine (para-like) with a series of aryloxide ions were studied in methanol at different temperatures. Plots of ΔH* versus ΔS* for both reactions gave good straight lines with isokinetic temperatures of 168 and 195°C. Good linear relationships were obtained from the plots of log k2 against σ° values with relatively large negative ρ values indicating the formation of Meisenheimer σ-complex intermediates. Plots of log k2 against pKa values gave good straight lines indicating that the reactions show an appreciable degree of bond formation in the transition state. An addition-elimination mechanism is suggested. Copyright
