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(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide is a chiral compound characterized by its specific stereochemistry, with both the α and β positions being in the R configuration. It features a 2,4-difluorophenyl group attached to a β-hydroxy-α-methyl-1H-1,2,4-triazole core, which is further connected to a butanamide group. This complex structure endows it with unique chemical properties, making it a valuable component in the synthesis of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide is used as an intermediate in the synthesis of triazole antifungal agents for the treatment of various fungal infections. Its unique structure allows for the development of potent and selective antifungal drugs that can target specific fungal enzymes or pathways, leading to effective treatment with minimal side effects.
Used in Agrochemical Industry:
(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide is also used as a key component in the preparation of triazole-based fungicides for agricultural applications. These fungicides are designed to protect crops from a wide range of fungal diseases, ensuring higher yields and better quality produce. The chiral nature of (αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide allows for the development of highly effective and environmentally friendly agrochemicals.
Chemical Properties:
(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanaMide is a white solid, indicating its stability and suitability for use in various chemical reactions and formulations. Its solid-state properties make it easier to handle, store, and incorporate into pharmaceutical and agrochemical products.

219872-85-2

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219872-85-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 219872-85-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,8,7 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 219872-85:
(8*2)+(7*1)+(6*9)+(5*8)+(4*7)+(3*2)+(2*8)+(1*5)=172
172 % 10 = 2
So 219872-85-2 is a valid CAS Registry Number.

219872-85-2Relevant academic research and scientific papers

AN IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOLE DERIVATIVES

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, (2021/12/31)

The present invention relates to an improved process for the preparation of triazole derivatives such as ravuconazole and isavuconazole.

Carbon analogs of antifungal dioxane-triazole derivatives: Synthesis and in vitro activities

Uchida, Takuya,Somada, Atsushi,Kagoshima, Yoshiko,Konosu, Toshiyuki,Oida, Sadao

supporting information; experimental part, p. 6538 - 6541 (2009/10/02)

A new series of triazole compounds possessing a carbon atom in place of a sulfur atom were efficiently synthesized and their in vitro antifungal activities were investigated. The carbon analogs showed excellent in vitro activity against Candida, Cryptococcus, and Aspergillus species. The MICs of compound 1c against C. albicans ATCC24433, C. neoformans TIMM1855, and A. fumigatus ATCC26430 were 0.016, 0.016, and 0.125 μg/mL, respectively (MICs of fluconazole: 0.5, >4, and >4 μg/mL; MICs of itraconazole: 0.125, 0.25, and 0.25 μg/mL).

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