219903-26-1

Upstream product

• 267641-89-4 (1aR,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-6-((E)-(R)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene 
• 51231-24-4 (20S)-(6β-Methoxy-20-methyl-3α,5-cyclo-5α-pregnan-21-ol)-p-toluolsulfonat 
• 51231-25-5 3α,5-cyclo-22-iodo-5α-23,24-bisnorcholan-6β-ol 6-methyl ether 
• 51231-23-3 3α,5-cyclo-22-hydroxy-5α-23,24-bisnorcholan-6β-ol 6-methyl ether 
• 32345-19-0 24-ethylcholesta-5,22-dien-3β-ol 
• 873-55-2 sodium benzenesulfonate 
• 85639-62-9 3α,5-cyclo-22-phenylsulfonyl-5α-23,24-bisnorcholan-6β-ol 6-methyl ether 
• 870-63-3 prenyl bromide 

Downstream Products

• 77058-74-3 (24S)-24,25-epoxycholesterol 
• 93528-37-1 24(R),25-Epoxycholesterol 

Relevant academic research and scientific papers

Efficient, stereoselective synthesis of 24(s), 25-epoxycholesterol

Efficient, stereoselective syntheses of 24(S), 25-epoxycholesterol (1) have been developed starting from cholenic acid (4) or stigmasterol (8), both featuring as the key step Sharpless asymmetric dihydroxylation of desmosterol acetate (2). This work permits preparation of gram quantities of 1 for further evaluation as a natural regulator of cholesterol metabolism, specifically, e.g., as a ligand for the LXRα. nuclear receptor.