219916-54-8

Upstream product

• 50-00-0 formaldehyd 
• 205517-34-6 (3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione 

Downstream Products

• 219916-57-1 (3S,6S)-N,N'-bis(4-methoxybenzyl)-3-isopropyl-6-n-pentylpiperazine-2,5-dione 
• 219916-58-2 (3S,6S)-N,N'-bis(4-methoxybenzyl)-3-isopropyl-6-ethylpiperazine-2,5-dione 
• 219916-55-9 (3S,6S)-N,N'-bis(4-methoxybenzyl)-3-isopropyl-6-neopentylpiperazine-2,5-dione 
• 219916-60-6 (3S,6S)-N,N'-bis-(4-methoxybenzyl)-3-isopropyl-6-isobutylpiperazine-2,5-dione 
• 219916-56-0 (3S,6S)-N,N'-bis(4-methoxybenzyl)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione 
• 216319-94-7 (3S,6S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-6-benzyl-piperazine-2,5-dione 
• 652140-19-7 (3S,6S)-4,7-bis(4-methoxybenzyl)-1,1-dimethyl-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione 
• 652140-58-4 (3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione 
• 72-18-4 L-valine 
• 4818-08-0 N-Z-L-phenylalanyl-L-valine methylester 
• 6306-52-1 L-valine methylester hydrochloride 
• 17498-50-9 L-valine hydrochloride 
• 35590-86-4 (3S,6S)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione 
• 5625-50-3 (3S,6S)-3-(1-methylethyl)-6-(2-methylpropyl)piperazine-2,5-dione 

Relevant academic research and scientific papers

Stereoselective conjugate addition of organocuprates to a dehydroalanine derived diketopiperazine

An asymmetric synthesis of homochiral α-amino acids has been developed which is based on the conjugate addition of organocuprates to the dehydroalanine equivalent (3S)-N,N′-bis(p-methoxybenzyl)-3-isopropyl-6-methylenepiperazine-2,5-dione 6.

Conjugate additions of organocuprates to a 3-methylene-6-isopropyldiketopiperazine acceptor for the asymmetric synthesis of homochiral α-amino acids

Addition of a range of organocuprates to (S)-N,N′-bis(p-methoxybenzyl)-3-methylene-6-isopropylpiperazine-2, 5-dione 8 affords cis-3-isopropyl-6-alkyldiketopiperazines in excellent yield and >95% de. Subsequent deprotection and hydrolysis of these cis-3-isopropyl-6-alkyldiketopiperazines affords homochiral (S)-α-amino acids in excellent yield.