349536-25-0

Basic information

• Product Name: (2S)-N-[5'-methoxy-4'-[(3''-methoxycarbonylpropyl)oxy]-2'-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal
• Synonyms: (2S)-N-[5'-methoxy-4'-[(3''-methoxycarbonylpropyl)oxy]-2'-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal
• CAS NO: 349536-25-0
• Molecular Weight: 500.637
• Mol File: 349536-25-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2S)-N-[5'-methoxy-4'-[(3''-methoxycarbonylpropyl)oxy]-2'-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-N-[5'-methoxy-4'-[(3''-methoxycarbonylpropyl)oxy]-2'-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal(349536-25-0)
• EPA Substance Registry System: (2S)-N-[5'-methoxy-4'-[(3''-methoxycarbonylpropyl)oxy]-2'-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal(349536-25-0)

Safety Data

• Hazardous Substances Data: 349536-25-0(Hazardous Substances Data)

Upstream product

• 349536-24-9 4-[(3'-methoxycarbonylpropyl)oxy]-3-methoxy-2-nitrobenzoic acid 
• 349536-23-8 4-[(3'-carboxypropyl)oxy]-3-methoxy-2-nitrobenzoic acid 
• 349536-22-7 4-[(3'-carboxypropyl)oxy]-3-methoxybenzoic acid 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 4897-84-1 Methyl 4-bromobutyrate 
• 140647-02-5 (2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 105089-88-1 (2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole 
• 773873-04-4 4-(3-ethoxycarbonyl-propoxy)-3-methoxy-benzoic acid 
• 127810-77-9 (2S)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl dithioacetal 

Downstream Products

• 625457-64-9 4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-N-chrysen-6-yl-butyramide 
• 625457-62-7 4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-N-chrysen-6-yl-butyramide 
• 642478-91-9 N-[(3S,5S)-1-(4-Benzyloxy-5-methoxy-2-nitro-benzoyl)-5-(bis-ethylsulfanyl-methyl)-pyrrolidin-3-yl]-4-{4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyramide 
• 642478-94-2 N-[(3S,5S)-1-(2-Amino-4-benzyloxy-5-methoxy-benzoyl)-5-(bis-ethylsulfanyl-methyl)-pyrrolidin-3-yl]-4-{5-amino-4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyramide 
• 642479-06-9 N-(8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl)-4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyramide 
• 642479-09-2 4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-N-(8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl)-butyramide 
• 219931-70-1 (2S)-N-{5-methoxy-4-[3-(carboxy)propyloxy]-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl dithioacetal 

Relevant articles and documents

Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c][1,4]benzodiazepine hybrids

Pyrene-linked pyrrolobenzodiazepine hybrids have been synthesized that exhibit potential anticancer activity in a number of human tumour cell lines. These hybrids also exhibit much enhanced DNA-binding ability in comparison to the parent pyrrolobenzodiazepine ring system (DC-81).

Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

The synthesis of new A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]- benzodiazepine dimers have been described in this report. These dimers exhibit significant DNA-binding ability with moderate anticancer activity.