219949-95-8

Basic information

• Product Name: ETHYL 4-HYDROXY-3-METHYLQUINOLINE-2-CARBOXYLATE
• Synonyms: ETHYL 4-HYDROXY-3-METHYLQUINOLINE-2-CARBOXYLATE;4-Hydroxy-3-methylquinoline-2-carboxylic acid ethyl ester;2-Quinolinecarboxylic acid, 4-hydroxy-3-methyl-, ethyl ester
• CAS NO: 219949-95-8
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.25
• EINECS: 1533716-785-6
• Mol File: 219949-95-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 178℃
• Appearance: /
• CAS DataBase Reference: ETHYL 4-HYDROXY-3-METHYLQUINOLINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-HYDROXY-3-METHYLQUINOLINE-2-CARBOXYLATE(219949-95-8)
• EPA Substance Registry System: ETHYL 4-HYDROXY-3-METHYLQUINOLINE-2-CARBOXYLATE(219949-95-8)

Safety Data

• Hazardous Substances Data: 219949-95-8(Hazardous Substances Data)

Usage

General Description

ETHYL 4-HYDROXY-3-METHYLQUINOLINE-2-CARBOXYLATE is a chemical compound that belongs to the quinoline carboxylate class of compounds. It is an ester derivative of 4-hydroxy-3-methylquinoline-2-carboxylic acid, and it has a molecular formula of C14H13NO4. ETHYL 4-HYDROXY-3-METHYLQUINOLINE-2-CARBOXYLATE is commonly used in pharmaceutical and medicinal chemistry research as a precursor or intermediate in the synthesis of various drugs and pharmaceuticals. It has potential applications in the development of anti-inflammatory, anti-cancer, and antimicrobial agents and is also used in the development of various other organic compounds.

Upstream product

• 86119-84-8 phosphoric acid 
• 62-53-3 aniline 
• 759-65-9 diethyl oxalpropionate 
• 59946-31-5 C₁₅H₁₉NO₄ 
• 408532-32-1 diethyl 2‐methyl-3‐(phenylimino)succinate 

Downstream Products

• 858488-66-1 3-Methyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid 
• 63136-60-7 4-chloro-3-methylquinoline 
• 1379615-35-6 3-methyl-2-(1-(4‐(trifluoromethoxy)benzyl)‐1H‐pyrazol‐4-yl)quinolin‐4(1H)‐one 
• 1379615-61-8 4‐chloro-3-methyl‐2‐(1‐(4‐(trifluoromethoxy)benzyl)-1H‐pyrazol‐4‐yl)quinoline 
• 1616959-50-2 2-(biphenyl-4-ylcarbamoyl)-3-methylquinoline-4-carboxylic acid 
• 1616959-72-8 N-biphenyl-4-yl-4-hydroxy-3-methylquinoline-2-carboxamide 
• 1616959-90-0 C₂₄H₁₇N₃O 
• 1616959-81-9 C₂₄H₁₇F₃N₂O₄S 
• 64965-46-4 3-methylquinolin-4-ol 
• 923585-65-3 (R)-4-[4-(3,4-dimethylpiperazin-1-yl)phenylamino]-3-methylquinoline-2-carboxylic acid ethyl ester 
• 24782-23-8 4-chloro-3-methylquinoline-2-carboxylic acid ethyl ester 
• 858488-66-1 4-hydroxy-3-methylquinoline-2-carboxylic acid 

Relevant articles and documents

Synthesis and Antimicrobial Activity of Burkholderia-Related 4-Hydroxy-3-methyl-2-alkenylquinolines (HMAQs) and Their N-Oxide Counterparts

The Burkholderia genus offers a promising potential in medicine because of the diversity of biologically active natural products encoded in its genome. Some pathogenic Burkholderia spp. biosynthesize a specific class of antimicrobial 2-alkyl-4(1H)-quinolo

Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties

A series of 2-pyrazolyl quinolones has been designed and synthesized in 5-7 steps to optimize for both in vitro antimalarial potency and various in vitro drug metabolism and pharmacokinetics (DMPK) features. The most potent compounds display no cross-resistance with multidrug resistant parasite strains (W2) compared to drug sensitive strains (3D7), with IC50 (concentration of drug required to achieve half maximal growth suppression) values in the range of 15-33 nM. Furthermore, members of the series retain moderate activity against the atovaquone-resistant parasite isolate (TM90C2B). The described 2-pyrazoyl series displays improved DMPK properties, including improved aqueous solubility compared to previously reported quinolone series and acceptable safety margin through in vitro cytotoxicity assessment. The 2-pyrazolyl quinolones are believed to bind to the ubiquinone-reducing Qi site of the parasite bc1 complex, which is supported by crystallographic studies of bovine cytochrome bc1 complex.

Design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents

In continuation of our research for novel human dihydroorotate dehydrogenase (hDHODH) inhibitors, herein we reported design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives. Human DHODH enzyme inhibition a