21996-47-4

Basic information

• Product Name: (S)-3-(4-methoxybenzyl)piperazine-2,5-dione
• Synonyms: (S)-3-(4-methoxybenzyl)piperazine-2,5-dione
• CAS NO: 21996-47-4
• Molecular Weight: 234.255
• Mol File: 21996-47-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-3-(4-methoxybenzyl)piperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-methoxybenzyl)piperazine-2,5-dione(21996-47-4)
• EPA Substance Registry System: (S)-3-(4-methoxybenzyl)piperazine-2,5-dione(21996-47-4)

Safety Data

• Hazardous Substances Data: 21996-47-4(Hazardous Substances Data)

Upstream product

• 382641-00-1 C₁₈H₂₆N₂O₆ 
• 6230-11-1 O-Methyltyrosine 
• 17554-34-6 (2S)-2-[(benzyloxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid 
• 1628630-04-5 C₁₉H₂₈N₂O₆ 
• 53267-93-9 O-methyl-N-tert-butoxycarbonyl-L-tyrosine 
• 17193-43-0 O-methyl-L-tyrosine ethyl ester 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 907971-37-3 C₁₂H₁₈N₂O 

Relevant articles and documents

Acid-Stable Ester Linkers for the Solid-Phase Synthesis of Immobilized Peptides

A series of N-terminally Fmoc-protected linkers of the general formula Fmoc-X?CO?O?Y?COOH have been prepared, where X is ?NH?CH2?CH2- or -p-(aminomethyl)phenyl- and Y is ?(CH2)n? (n is 1 or 4) or -p-(methyl)phenyl-. These linkers can easily be covalently attached via their C-terminal carboxyl group to a resin bearing a free amino group. After cleavage of the N-terminal Fmoc group, the linkers can be extended by standard solid-phase peptide synthesis techniques. These ester linkers are acid-stable and resistant to the base-mediated diketopiperazine formation that often occurs during the synthesis of ester-bound peptides; they are stable at neutral pH in aqueous buffers for days but can be effectively cleaved with 0.1 m NaOH or aq. ammonia within minutes or hours, respectively. These properties make these ester handles well suited for use as linkers for the solid-phase peptide synthesis of immobilized peptides when the stable on-resin immobilization of the peptides and the testing of their biological properties in aqueous buffers at neutral pH are necessary.

Synthesis and conformational characterization of diketopiperazines bearing a benzyl moiety

Diketopiperazines bearing a benzyl moiety with different para-substituents were synthesized and analyzed by 1HNMR spectroscopy. All of these diketopiperazines were found to adopt a folded conformation according to the upfield chemical shift of the cis-proton (cis to the benzyl moiety) due to a shielding effect in the 1HNMR spectra. An intramolecular CH-π interaction appears to be an important factor for the folded conformation due to the effects of para-substituents on the benzyl group.

PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS

Described herein are antipyschotic compounds of formula (I) wherein, A is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, O, and S; Alk is (C1-4) alkylene optionally substituted w