219965-98-7Relevant academic research and scientific papers
Silicon-phthalocyanine-cored fullerene dendrimers: Synthesis and prolonged charge-separated states with dendrimer generations
El-Khouly, Mohamed E.,Kang, Eui Su,Kay, Kwang-Yol,Choi, Chan Soo,Aaraki, Yasuyuki,Ito, Osamu
, p. 2854 - 2863 (2007)
Silicon-phthalocyanine-cored fullerodendrimers with up to eight fullerene substituants (SiPc-n C60; n = 2, 4, and 8) have been synthesized. Photophysical properties of newly synthesized SiPc-n C60 have been investigated by time-resol
Preparation of polymer films containing multi-branched chromophores for enhanced nonlinear optical activity
Lin, Wenxin,Cui, Yuanjing,Yu, Jiancan,Yang, Yu,Qian, Guodong
, p. 791 - 797 (2016/09/28)
Two new multi-branched chromophores were synthesized via esterification from monochromophores to achieve ideal macroscopic nonlinear optical activities. Molecular chemical structures of chromophores were confirmed by 1H NMR, FT-IR spectroscopy,
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L
Parker, Erica N.,Song, Jiangli,Kishore Kumar,Odutola, Samuel O.,Chavarria, Gustavo E.,Charlton-Sevcik, Amanda K.,Strecker, Tracy E.,Barnes, Ashleigh L.,Sudhan, Dhivya R.,Wittenborn, Thomas R.,Siemann, Dietmar W.,Horsman, Michael R.,Chaplin, David J.,Trawick, Mary Lynn,Pinney, Kevin G.
, p. 6974 - 6992 (2015/11/11)
Upregulation of cathepsin L in a variety of tumors and its ability to promote cancer cell invasion and migration through degradation of the extracellular matrix suggest that cathepsin L is a promising biological target for the development of anti-metastatic agents. Based on encouraging results from studies on benzophenone thiosemicarbazone cathepsin inhibitors, a series of fourteen benzoylbenzophenone thiosemicarbazone analogues were designed, synthesized, and evaluated for their inhibitory activity against cathepsins L and B. Thiosemicarbazone inhibitors 3-benzoylbenzophenone thiosemicarbazone 1, 1,3-bis(4-fluorobenzoyl)benzene thiosemicarbazone 8, and 1,3-bis(2-fluorobenzoyl)-5-bromobenzene thiosemicarbazone 32 displayed the greatest potency against cathepsin L with low IC50 values of 9.9 nM, 14.4 nM, and 8.1 nM, respectively. The benzoylbenzophenone thiosemicarbazone analogues evaluated were selective in their inhibition of cathepsin L compared to cathepsin B. Thiosemicarbazone analogue 32 inhibited invasion through Matrigel of MDA-MB-231 breast cancer cells by 70% at 10 μM. Thiosemicarbazone analogue 8 significantly inhibited the invasive potential of PC-3ML prostate cancer cells by 92% at 5 μM. The most active cathepsin L inhibitors from this benzoylbenzophenone thiosemicarbazone series (1, 8, and 32) displayed low cytotoxicity toward normal primary cells [in this case human umbilical vein endothelial cells (HUVECs)]. In an initial in vivo study, 3-benzoylbenzophenone thiosemicarbazone (1) was well-tolerated in a CDF1 mouse model bearing an implanted C3H mammary carcinoma, and showed efficacy in tumor growth delay. Low cytotoxicity, inhibition of cell invasion, and in vivo tolerability are desirable characteristics for anti-metastatic agents functioning through an inhibition of cathepsin L. Active members of this structurally diverse group of benzoylbenzophenone thiosemicarbazone cathepsin L inhibitors show promise as potential anti-metastatic, pre-clinical drug candidates.
Self-assembly and liquid-crystalline supramolecular organizations of semifluorinated block co-dendritic supermolecules
Bury, Izabela,Heinrich, Benoit,Bourgogne, Cyril,Mehl, Georg H.,Guillon, Daniel,Donnio, Bertrand
, p. 452 - 468 (2012/03/22)
The synthesis and self-organizing behaviour into liquid-crystalline mesophases of two libraries of segmented block co-dendrimers are described. The overall structure of the dendritic supermolecules consists of two chemically incompatible molecular moietie
Design and synthesis of bichromophores for nonlinear optical applications in polymer films
Gao, Junkuo,Cui, Yuanjing,Yu, Jiancan,Lin, Wenxin,Wang, Zhiyu,Qian, Guodong
scheme or table, p. 496 - 501 (2012/03/10)
Three bichromophores were designed and synthesized by linking a vinylthiophene-conjugated chromophore with different tether groups via esterification. Second harmonic generation measurements of nonlinear polymer films revealed that the second harmonic gen
Dendron rodcoils: Synthesis of novel organic hybrid structures
Zubarev, Eugene R.,Stupp, Samuel I.
, p. 5762 - 5773 (2007/10/03)
Convergent and divergent syntheses of novel organic hybrid structures termed dendron rodcoils (DRC) containing dendritic, rodlike, and coillike segments are described. The aryl ester dendron masked with 32 trifluoromethyl groups is prepared via a converge
