219986-59-1

Basic information

• Product Name: 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide
• Synonyms: 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide
• CAS NO: 219986-59-1
• Molecular Weight: 303.308
• Mol File: 219986-59-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide(219986-59-1)
• EPA Substance Registry System: 5-hydroxy-3-p-tolyl-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide(219986-59-1)

Safety Data

• Hazardous Substances Data: 219986-59-1(Hazardous Substances Data)

Upstream product

• 79-19-6 thiosemicarbazide 
• 187812-31-3 1,1,1-trifluoro-4-methoxy-4-(4-methylphenyl)-3-buten-2-one 

Downstream Products

• 219986-64-8 3-p-tolyl-5-(trifluormethyl)-1H-pyrazole 

Relevant articles and documents

Haloacetylated enol ethers 10. Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide. Synthesis of new trifluoromethyl 4,5-dihydro-1H-1-pyrazolethiocarboxyamides

The synthesis of 3-aryl[alkyl]-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- pyrazolethiocarboxyamides (2a-g) from the direct cyclo-condensation reaction of β-alkoxyvinyl trifluoromethyl ketones (1a-g) with thiosemicarbazide in methanol, under mild conditions, is reported. Similarly, the 1H-1-pyrazolethiocarboxyamide derivatives (2a-g) were easily dehydrated and the thiocarboxyamide group hydrolyzed in a one-step reaction by stirring with concentrated sulfuric acid to give the 3-aryl[alkyl]-5-trifluoromethyl-1H-pyrazoles (3a-g) in good yields. Specific syntheses and physical properties of 3-aryl[alkyl]-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- pyrazolethiocarboxyamides are reported here for the first time.