219989-24-9

Basic information

• Product Name: 5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE
• Synonyms: 5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE
• CAS NO: 219989-24-9
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Mol File: 219989-24-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE(219989-24-9)
• EPA Substance Registry System: 5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE(219989-24-9)

Safety Data

• Hazardous Substances Data: 219989-24-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE is used as a pharmaceutical agent for its potential effects on the central nervous system. It is being studied for its ability to interact with specific receptors, which may contribute to the development of new treatments for neurological disorders or conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE serves as a valuable building block. It is utilized for the production of other chemical compounds, contributing to the creation of novel molecules with diverse applications across various industries.
Further research is necessary to fully understand the scope of 5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE's applications and to optimize its use in these industries. As our understanding of 5,6,7,8-TETRAHYDRO-4H-FURO[3,2-B]AZEPINE grows, so too may its applications expand, potentially leading to new breakthroughs in medicine and chemical manufacturing.

Upstream product

• 180339-33-7 4,5,6,7-tetrahydrobenzo[b]furan-4-one (Z)-oxime 
• 61190-46-3 6,7-dihydro-1-benzofuran-4(5H)-one oxime 
• 16806-93-2 4-oxo-4,5,6,7-tetrahydrobenzofuran 

Downstream Products

• 186808-27-5 (4-Nitro-phenyl)-(5,6,7,8-tetrahydro-furo[3,2-b]azepin-4-yl)-methanone 

Relevant articles and documents

Synthesis and Structure-Activity Relationships of 5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepine Derivatives: Novel Arginine Vasopressin Antagonists

A variety of novel heterocyclic compounds having thienoazepine, pyrroloazepine, furoazepine, and thienodiazepine skeletons were synthesized, most of which exhibited potent antagonism of [3H]-AVP specific binding in assays using rat liver (V1), rat kidney (V2), human platelet plasma membranes, and recombinant human CHO cells (V2), as well as antagonizing AVP-induced hypertension in rats (V1, intravenous) and showing a diuretic effect in rats (V2, oral). By detailed studies of the structure-activity relationships of these compounds, the thienoazepine derivative 1 was found to be a very potent combined V1 and V2 antagonist. After further pharmacological and toxicological evaluation as well as physical properties, the hydrochloride 2 (JTV-605) of compound 1 was selected for clinical studies as a potent AVP antagonist with a long duration of action.

Regioselective synthesis of several heterocyclic fused azepines using diisobutylaluminum hydride

5,6,7,8-Tetrahydrothieno[3,2-b]azepine,5,6,7,8-tetrahydro-1H-furo[3,2-b] azepine, and 1,4,5,6,7,8-hexahydropyrrolo[3,2-b]azepine were synthesized by the ring expansion reaction of heterocyclic fused cyclohexanone oximes with diisobutylaluminum hydride (DIBAH). The mechanism of the reaction was different from that of Beckmann rearrangement.