16806-93-2

Basic information

• Product Name: 6,7-Dihydro-4(5H)-benzofuranone
• Synonyms: 6,7-DIHYDRO-1-BENZOFURAN-4(5H)-ONE;6,7-DIHYDRO-4(5H)-BENZOFURANONE;6,7-Dihydro-4(5H)-benzofuranone, GC 98%;6,7-DIHYDRO-4(5H)-BENZOFURANONE 98%;6,7-Dihydro-4(5H)-benzofuranone,98%;2,3-Dihydro-4(5H)-benzofuranone;6,7-dihydrobenzofuran-4(5H)-one;6,7-Dihydro-4(5H)-be
• CAS NO: 16806-93-2
• Molecular Formula: C₈H₈O₂
• Molecular Weight: 136.15
• Product Categories: Benzofurans;Building Blocks;Heterocyclic Building Blocks
• Mol File: 16806-93-2.mol
• Article Data: 27

Chemical Properties

• Melting Point: 30-34 °C(lit.)
• Boiling Point: 115-118 °C16 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow to brown/Liquid
• Density: 1.162 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0714mmHg at 25°C
• Refractive Index: 1.53-1.532
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 6,7-Dihydro-4(5H)-benzofuranone(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dihydro-4(5H)-benzofuranone(16806-93-2)
• EPA Substance Registry System: 6,7-Dihydro-4(5H)-benzofuranone(16806-93-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 16806-93-2(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to brown low melting solid or liquid

Uses

6,7-Dihydro-4(5H)-benzofuranone may be used in the synthesis of furacridone ring skeleton.

Synthesis Reference(s)

Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-OTetrahedron Letters, 27, p. 1127, 1986 DOI: 10.1016/S0040-4039(00)84195-7

General Description

6,7-Dihydro-4(5H)-benzofuranone is a benzofuran derivative that consists of fused benzene and furan ring. Its standard molar enthalpy of formation by static bomb calorimetry and standard molar enthalpy of vaporization using Calvet microcalorimetry has been measured. These values have been used to derive the standard molar enthalpy of formation in gaseous phase.

InChI:InChI=1/C8H8O2/c9-7-2-1-3-8-6(7)4-5-10-8/h4-5H,1-3H2

Upstream product

• 107-20-0 2-chloroethanal 
• 30182-67-3 1,3-Cyclohexanedione 
• 504-02-9 1,3-cylohexanedione 
• 150-78-7 1,4-dimethoxybezene 
• 75-35-4 1,1-Dichloroethylene 
• 1460-08-8 2-diazocyclohexane-1,3-dione 
• 119-61-9 benzophenone 
• 84099-58-1 4-hydroxy-4,5,6,7-tetrahydrobenzofuran 
• 183495-78-5 2-phenylsulfanyl-3,5,6,7-tetrahydro-2H-benzofuran-4-one 
• 66144-45-4 4-Furan-2-yl-butyryl chloride 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 35768-38-8 3-hydroxy-3,5,6,7-tetrahydro-2H-benzofuran-4-one 
• 108-05-4 vinyl acetate 

Downstream Products

• 61190-46-3 6,7-dihydro-1-benzofuran-4(5H)-one oxime 
• 180339-33-7 4,5,6,7-tetrahydrobenzo[b]furan-4-one (Z)-oxime 
• 180339-32-6 4,5,6,7-tetrahydrobenzo[b]furan-4-one (E)-oxime 
• 1305646-33-6 C₁₅H₁₅NO₂ 
• 13618-91-2 4,5,6,7-tetrahydroindole 
• 1370513-55-5 C₁₄H₁₄BrN 
• 1370513-56-6 C₁₄H₁₄ClN 
• 1370513-57-7 C₁₅H₁₇NO 
• 23922-51-2 1-p-Tolyl-4,5,6,7-tetrahydroindol-4-on 
• 141694-09-9 1-p-tolyl-4,5,6,7-tetrahydro-1H-indole 
• 68394-68-3 1-(p-Chlorophenyl)-4,5,6,7-tetrahydroindole 
• 213183-59-6 C₁₅H₁₅NO₂ 
• 68394-66-1 1-(p-Methoxyphenyl)-4,5,6,7-tetrahydroindole 
• 1415251-48-7 (E)-4-(4-chlorophenyl)-2-(2-(6,7-dihydrobenzofuran-4(5H)-ylidene)hydrazinyl)thiazole 

Relevant articles and documents

A concise new synthesis of angular furanocoumarins: Angelicin, oroselone and oroselol

An efficient synthesis of angular furanocoumarins has been carried out starting from dihydrobenzofuran derivatives.

A Convenient Synthesis of 4-tert-Butyl-5-benzofuranols and Dihydrobenzofuranols

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Preparation method of polysubstituted furan compound

The invention discloses a preparation method of a polysubstituted furan compound, which comprises the following steps: by using a carbonyl compound with an electron withdrawing group at the alpha position and dichloroolefin as raw materials, reacting under alkaline conditions to obtain a 2, 3-disubstituted furan compound and a 2, 3, 5-trisubstituted furan compound. The method has the advantages ofno need of transition metal catalysis, strong substrate applicability, cheap and easily available raw materials, simple operation, high efficiency and wide application prospect.

Transition-Metal-Free Approach to Polysubstituted Furans

A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of β-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance.