219993-31-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 101250-48-0 (S)-5-benzylmorpholin-3-one 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2382-86-7 methyl (S)-2-(2-chloroacetamido)-3-phenylpropanoate 
• 94193-78-9 (S)-2-chloro-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide 
• 3182-95-4 L-Phenylalaninol 

Downstream Products

• 1607483-19-1 C₁₆H₂₃NO₄ 
• 1607483-20-4 C₁₇H₂₅NO₄ 
• 1607483-23-7 C₁₃H₂₀NO₄P 
• 1621604-13-4 (3R,5S)-5-benzylmorpholine-3-phosphonic acid 
• 913263-44-2 (2R,5S)-2-Allyl-5-benzyl-3-oxo-morpholine-4-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Diastereoselective synthesis of novel 5-substituted morpholine-3-phosphonic acids: Further exploitation of N-acyliminium intermediates

The first diastereoselective total synthesis of 5-substituted morpholine-3-phosphonic acids is reported. The principal feature of the synthesis is the introduction of a dimethyl phosphonate group into 5-substituted morpholin-3-ones. The procedure is based

New, potent P1/P2-morpholinone-based HIV-protease inhibitors

We have developed efficient synthesis of morpholinone-based cyclic mimetics of the P1/P2 portion of the HIV-1 protease inhibitor Amprenavir. This effort led to discovery of allyl- and spiro-cyclopropyl-P2-substituted inhibitors 17 and 31, both 500 times m

Novel and efficient synthesis of spirocyclic morpholinones as precursors of ψ[CH2O] dipeptide isosteres

A series of novel dipeptide mimetics 4, featuring replacement of peptide bond by ψ[CH2O], was synthesized in high yields from their precursors, novel spirocyclic morpholinones 2. Efficient and reliable chemistry leading to 2 was accomplished by alkylating morpholinone 1 with 1-chloro-ω- iodoalkanes, followed by Finkelstein iodide exchange and LDA-mediated intramolecular spirocyclization.