219993-31-4

Basic information

• Product Name: 4-Morpholinecarboxylic acid, 3-oxo-5-(phenylmethyl)-, 1,1-dimethylethyl ester, (5S)-
• CAS NO: 219993-31-4
• Molecular Formula: C16H21NO4
• Molecular Weight: 291.347
• Mol File: 219993-31-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Morpholinecarboxylic acid, 3-oxo-5-(phenylmethyl)-, 1,1-dimethylethyl ester, (5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinecarboxylic acid, 3-oxo-5-(phenylmethyl)-, 1,1-dimethylethyl ester, (5S)-(219993-31-4)
• EPA Substance Registry System: 4-Morpholinecarboxylic acid, 3-oxo-5-(phenylmethyl)-, 1,1-dimethylethyl ester, (5S)-(219993-31-4)

Safety Data

• Hazardous Substances Data: 219993-31-4(Hazardous Substances Data)

Upstream product

• 94193-78-9 (S)-2-chloro-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide 
• 2382-86-7 methyl (S)-2-(2-chloroacetamido)-3-phenylpropanoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 3182-95-4 L-Phenylalaninol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 101250-48-0 (S)-5-benzylmorpholin-3-one 

Downstream Products

• 1607483-19-1 C₁₆H₂₃NO₄ 
• 1607483-20-4 C₁₇H₂₅NO₄ 
• 1607483-23-7 C₁₃H₂₀NO₄P 
• 1621604-13-4 (3R,5S)-5-benzylmorpholine-3-phosphonic acid 
• 913263-44-2 (2R,5S)-2-Allyl-5-benzyl-3-oxo-morpholine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

Diastereoselective synthesis of novel 5-substituted morpholine-3-phosphonic acids: Further exploitation of N-acyliminium intermediates

The first diastereoselective total synthesis of 5-substituted morpholine-3-phosphonic acids is reported. The principal feature of the synthesis is the introduction of a dimethyl phosphonate group into 5-substituted morpholin-3-ones. The procedure is based

Novel and efficient synthesis of spirocyclic morpholinones as precursors of ψ[CH2O] dipeptide isosteres

A series of novel dipeptide mimetics 4, featuring replacement of peptide bond by ψ[CH2O], was synthesized in high yields from their precursors, novel spirocyclic morpholinones 2. Efficient and reliable chemistry leading to 2 was accomplished by alkylating morpholinone 1 with 1-chloro-ω- iodoalkanes, followed by Finkelstein iodide exchange and LDA-mediated intramolecular spirocyclization.