219996-75-5Relevant academic research and scientific papers
Synthesis of diacylglycerol analogs of phosphatidylinositol 3,4,5- trisphosphate
Shirai, Ryuichi,Morita, Koji,Nishikawa, Asuka,Nakatsu, Noriyuki,Fukui, Yasuhisa,Morisaki, Naoko,Hashimoto, Yuichi
, p. 9485 - 9488 (1998)
Phosphatidylinositol 3,4,5-trisphosphate analogs with saturated diacylglycerol substructure have been designed, focusing on their reactivity with PIP3 5-phosphatase. Dephosphorylation of native PIP3 was competitively inhibited in the presence of synthetic PIP3(C2) and PIP3(C4), respectively.
Phosphorylation of unnatural phosphatidylinositols with phosphatidylinositol 3-kinase
Morisaki, Naoko,Morita, Koji,Nishikawa, Asuka,Nakatsu, Noriyuki,Fukui, Yasuhisa,Hashimoto, Yuichi,Shirai, Ryuichi
, p. 2603 - 2614 (2007/10/03)
Phosphatidylinositol analogs (PI(C2)-PI(C18)) having a series of saturated fatty acid (C2-C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3- kinase). The reactivity of Pica with PI 3-kinase turned out to be comparable to that of natural PI, although PI(C18) was not phosphorylated under the same condition. The chirality of sn-2 center was not responsible for the phosphorylation reaction. (C) 2000 Elsevier Science Ltd.
The structural requirement of phosphatidylinositols as substrate of phosphatidylinositol 3-kinase
Shirai, Ryuichi,Morita, Koji,Nishikawa, Asuka,Nakatsu, Noriyuki,Fukui, Yasuhisa,Morisaki, Naoko,Hashimoto, Yuichi
, p. 1693 - 1696 (2007/10/03)
Synthetic distearate phosphatidylinositol (PI) was not phosphorylated by PI 3-kinase. The fatty acids at glycerol sn-2 must be as short as octanoic acid or less to act as a substrate of PI 3-kinase.
