Synthesis of diacylglycerol analogs of phosphatidylinositol 3,4,5- trisphosphate

DOI: 10.1016/S0040-4039(98)02151-0

Source and publish data:

Tetrahedron Letters p. 9485 - 9488 (1998)

Update date:2022-09-26

Topics: Synthesis Analog Experimental

Authors:

Shirai, Ryuichi

Morita, Koji

Nishikawa, Asuka

Nakatsu, Noriyuki

Fukui, Yasuhisa

Morisaki, Naoko

Hashimoto, Yuichi

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Article abstract of DOI:10.1016/S0040-4039(98)02151-0

Phosphatidylinositol 3,4,5-trisphosphate analogs with saturated diacylglycerol substructure have been designed, focusing on their reactivity with PIP3 5-phosphatase. Dephosphorylation of native PIP3 was competitively inhibited in the presence of synthetic PIP3(C2) and PIP3(C4), respectively.

Full text of DOI:10.1016/S0040-4039(98)02151-0

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