Tetrahedron Letters p. 9485 - 9488 (1998)
Update date:2022-09-26
Topics: Synthesis Analog Experimental
Shirai, Ryuichi
Morita, Koji
Nishikawa, Asuka
Nakatsu, Noriyuki
Fukui, Yasuhisa
Morisaki, Naoko
Hashimoto, Yuichi
Phosphatidylinositol 3,4,5-trisphosphate analogs with saturated diacylglycerol substructure have been designed, focusing on their reactivity with PIP3 5-phosphatase. Dephosphorylation of native PIP3 was competitively inhibited in the presence of synthetic PIP3(C2) and PIP3(C4), respectively.
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