220010-47-9

Upstream product

• 220010-61-7 (S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide 
• 220010-60-6 4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-dithiobenzoic acid methyl ester 
• 220010-58-2 N-[[(5S)-3-[3-fluoro-4-nitrile-phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide 
• 181997-31-9 N-{[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide 
• 220009-99-4 (S)-N-[[3-[3-Fluoro-4-[5-[(methylthio)methyl]-1,3,4-thiadiazol-2-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 

Relevant academic research and scientific papers

The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues

Replacement of the morpholine C-ring of linezolid 1 with a 1,3,4-thiadiazolyl ring leads to oxazolidinone analogues 5 having potent antibacterial activity against both gram-positive and gram-negative organisms. Conversion of the C5 acetamide group to a thioacetamide further increases the potency of these compounds.

Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents

The present invention provides thiadiazolyl and oxadiazolyl phenyl oxzolidinone compounds of formula I STR1 wherein Q is thiadiazolyl or oxadiazolyl; wherein X1 and X2 are independently hydrogen, fluorine or chlorine; and wherein R1 is, for example, --COCH3 or --COCH2 CH3. These compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive and gram-negative aerobic bacteria.