220024-87-3

Basic information

• Product Name: Pyrrolidine, 2,2-dimethyl-1-(phenylmethyl)-
• CAS NO: 220024-87-3
• Molecular Formula: C13H19N
• Molecular Weight: 189.301
• Mol File: 220024-87-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 2,2-dimethyl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 2,2-dimethyl-1-(phenylmethyl)-(220024-87-3)
• EPA Substance Registry System: Pyrrolidine, 2,2-dimethyl-1-(phenylmethyl)-(220024-87-3)

Safety Data

• Hazardous Substances Data: 220024-87-3(Hazardous Substances Data)

Upstream product

• 5291-77-0 1-benzyl-2-pyrrolidone 
• 75-16-1 methylmagnesium bromide 
• 917-54-4 methyllithium 
• 144310-39-4 1-benzyl-5-methylsulfanyl-3,4-dihydro-2H-pyrrolium iodide 
• 94616-84-9 dichloromethylcerium 
• 17642-88-5 1-benzyl-2-pyrrolidinethione 

Relevant articles and documents

Synthesis, spectral, and anti-microbial studies of thioiminium iodides and amine hydrochlorides

To avoid the undesired deprotonation during the addition of organolithium and organomagnesium reagents to ketones, the thioiminium salts, easily prepared from lactams and amides are converted into 2,2-disubstituted and 2-monosubstituted amines by reaction with simple nucleophiles such as organocerium and organocopper reagents. The reaction of thioiminium iodides with organocerium reagents derived by transmetalation of corresponding lithium reagents with anhydrous cerium(III) chloride has been investigated. These thioiminium iodides act as good electrophiles and accept alkylceriums towards bisaddition. The newly synthesized amines have been characterized by 1H and 13C NMR, IR and mass spectra. The amines have been converted into their hydrochlorides and characterized by COSY. These hydrochlorides have been subjected to antimicrobial screening with clinically isolated microorganisms, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi and Candida albicans. The hydrochlorides show quite good activity against these bacteria and fungus.

3- Or 4-monosubstituted phenol derivatives useful as H3 ligands

The invention relates to 3- or 4-monosubstituted phenol derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.