220024-87-3Relevant academic research and scientific papers
Synthesis, spectral, and anti-microbial studies of thioiminium iodides and amine hydrochlorides
Britto, Sebastian,Renaud, Philippe,Nallu, Maruthai
, p. 489 - 493 (2013/12/04)
To avoid the undesired deprotonation during the addition of organolithium and organomagnesium reagents to ketones, the thioiminium salts, easily prepared from lactams and amides are converted into 2,2-disubstituted and 2-monosubstituted amines by reaction with simple nucleophiles such as organocerium and organocopper reagents. The reaction of thioiminium iodides with organocerium reagents derived by transmetalation of corresponding lithium reagents with anhydrous cerium(III) chloride has been investigated. These thioiminium iodides act as good electrophiles and accept alkylceriums towards bisaddition. The newly synthesized amines have been characterized by 1H and 13C NMR, IR and mass spectra. The amines have been converted into their hydrochlorides and characterized by COSY. These hydrochlorides have been subjected to antimicrobial screening with clinically isolated microorganisms, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi and Candida albicans. The hydrochlorides show quite good activity against these bacteria and fungus.
An efficient method to convert lactams and amides into 2,2-dialkylated amines
Agosti, Alessandro,Britto, Sebastian,Renaud, Philippe
supporting information; experimental part, p. 1417 - 1420 (2009/04/12)
(Chemical Equation Presented) A practical method for the synthesis of gem-2,2-disubstituted tertiary amines from the corresponding lactams (or amides) is reported. It is based on the reaction of thioiminium ions, easily prepared from lactams and amides wi
3- Or 4-monosubstituted phenol derivatives useful as H3 ligands
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Page/Page column 95, (2010/02/14)
The invention relates to 3- or 4-monosubstituted phenol derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
A modified bouveault reaction for the preparation of a, a-dimethylamines from amides
Denton, Stephen M.,Wood, Anthony
, p. 55 - 56 (2007/10/03)
A modified Bouveault reaction1 for the efficient synthesis of a, a-dimethylamines from the corresponding amides is described. Thus, pretreatment of the amide with zirconium or titanium tetrachloride followed by reaction with an excess of methylmagnesium b
