220032-26-8

Basic information

• Product Name: 4-Amino-N-((4-piperidinyl)methyl)-5-chloro-2-methoxybenzamide
• Synonyms: 4-Amino-N-((4-piperidinyl)methyl)-5-chloro-2-methoxybenzamide;4-aMino-5-chloro-2-Methoxy-N-(piperidin-4-ylMethyl)benzaMide;BenzaMide, 4-aMino-5-chloro-2-Methoxy-N-(4-piperidinylMethyl)-;4-amino-5-chloro-2-methoxy-N-(4-piperidinylmethyl)Benzamide
• CAS NO: 220032-26-8
• Molecular Formula: C14H20ClN3O2
• Molecular Weight: 297.7805
• Mol File: 220032-26-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 452.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.01±0.46(Predicted)
• CAS DataBase Reference: 4-Amino-N-((4-piperidinyl)methyl)-5-chloro-2-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-N-((4-piperidinyl)methyl)-5-chloro-2-methoxybenzamide(220032-26-8)
• EPA Substance Registry System: 4-Amino-N-((4-piperidinyl)methyl)-5-chloro-2-methoxybenzamide(220032-26-8)

Safety Data

• Hazardous Substances Data: 220032-26-8(Hazardous Substances Data)

Usage

General Description

4-Amino-N-((4-piperidinyl)methyl)-5-chloro-2-methoxybenzamide is a chemical compound with the molecular formula C16H23ClN3O2. It is a derivative of the benzamide class of compounds and contains a piperidine ring, an amine group, a methoxy group, and a chlorine atom. 4-Amino-N-((4-piperidinyl)methyl)-5-chloro-2-methoxybenzamide is of interest in medicinal chemistry and pharmaceutical research due to its potential pharmacological properties. It may have applications as an analgesic, antipsychotic, or antitumor agent, among other potential uses. Further research is needed to fully understand and explore the potential uses and effects of this compound.

Upstream product

• 188973-04-8 N-tert-butyloxycarbonyl-4-(4-amino-5-chloro-2-methoxyphenylcarbonylaminomethyl)piperidine 
• 7206-70-4 4-amino-5-chloro-2-methoxybenzoic acid 
• 144222-22-0 tert-butyl 4-(aminomethyl)piperidine-1-carboxylate 

Relevant articles and documents

Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer's Disease: The Design of Donecopride

In this work, we describe the synthesis and in vitro evaluation of a novel series of multitarget-directed ligands (MTDL) displaying both nanomolar dual-binding site (DBS) acetylcholinesterase inhibitory effects and partial 5-HT4R agonist activity, among which donecopride was selected for further in vivo evaluations in mice. The latter displayed procognitive and antiamnesic effects and enhanced sAPPα release, accounting for a potential symptomatic and disease-modifying therapeutic benefit in the treatment of Alzheimer's disease. (Figure Presented).