220033-94-3

Upstream product

• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 259726-42-6 1-O-tert-Butyl-2,4,6-tri-O-acetyl-3-deoxy-β-L-glucopyranoside 
• 259726-43-7 (2R,3S,5R,6S)-2-tert-Butoxy-6-hydroxymethyl-tetrahydro-pyran-3,5-diol 

Downstream Products

• 259726-44-8 1-O-tert-Butyl-2-O-benzyl-4,6-O-p-methoxybenzylidene-3-deoxy-β-L-glucopyranoside 
• 220033-97-6 (R)-2-((2R,3S,5R,6S)-6-Azidomethyl-3-benzyloxy-5-isobutoxy-tetrahydro-pyran-2-yl)-propionic acid 
• 259726-49-3 (R)-2-((2R,3S,5R,6S)-6-Azidomethyl-3-benzyloxy-5-isobutoxy-tetrahydro-pyran-2-yl)-propionic acid tert-butyl ester 
• 220033-95-4 1-O-tert-Butyl-2-O-benzyl-4-O-p-methoxybenzyl-3,6-dideoxy-6-azido-β-L-glucopyranoside 
• 259726-47-1 1-O-tert-Butyl-2-O-benzyl-4-O-isobutyl-3,6-dideoxy-6-azido-β-L-glucopyranoside 
• 259726-45-9 [(2S,3R,5S,6R)-5-Benzyloxy-6-tert-butoxy-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-methanol 
• 259726-46-0 1-O-tert-Butyl-2-O-benzyl-3,6-dideoxy-6-azido-β-L-glucopyranoside 

Relevant academic research and scientific papers

Peptides peptide analogs peptidomimetics and other small molecules useful for inhibiting the activity of ribonucleotide reductase

The invention relates to compositions which are useful for inhibiting ribonucleotide reductase enzymes, including the mammalian ribonucleotide reductase enzyme. The compositions include, but are not limited to, linear peptides, cyclic peptides, peptide analogs, and peptidomimetics. Methods of using the compositions of the invention to treat cancer and viral and bacterial infections are disclosed.

Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase

A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.