259726-45-9Relevant academic research and scientific papers
Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase
Smith III, Amos B.,Sasho, Setsuya,Barwis, Bari A.,Sprengeler, Paul,Barbosa, Joseph,Hirschmann, Ralph,Cooperman, Barry S.
, p. 3133 - 3136 (2007/10/03)
A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.
