220035-08-5

Upstream product

• 133544-94-2 (S)-3-acetyl-4-benzyl-5-oxazolidinone 
• 63-91-2 L-phenylalanine 
• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 56-23-5 tetrachloromethane 

Downstream Products

• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 
• 103127-52-2 ((S)-1-benzylallyl)carbamic acid tert-butyl ester 
• 126410-30-8 (S)-1-phenylbut-3-en-2-amine 
• 220035-13-2 (S)-3-acetylamino-4-phenyl-1-butene 

Relevant academic research and scientific papers

Preparation method for amprenavir intermediate

The invention relates to a synthesis method for an amprenavir intermediate, an anti-AIDS drug, in particular to a synthesis method for (2R,3S)-1,2-epoxy-3-(tert-butoxycarbonylamino)-4-phenylbutane. The synthesis method comprises the following steps: reacting L-phenylalanine, as a raw material, with acetic anhydride to generate N-acetyl-L-phenylalanine, and then carrying out a Mannich reaction, an Appel reaction and olefin epoxidation to obtain an intermediate. The method for preparing the (2R,3S)-1,2-epoxy-3-(tert-butoxycarbonylamino)-4-phenylbutane is reasonable in route, high in operability and high in yield, and facilitates industrial production.

A novel and facile synthesis of C2-symmetric HIV - Protease inhibitors

A facile synthesis of C2-symmetric HIV protease inhibitors 7 and 10 is described via a novel dichloromethylenation of oxazolidinone 1 and its conversion to allyl amine 3.

A New Approach for Chiral Allyl Amines via a Novel Dichloromethylenation of Oxazolidinones

A novel dichloromethylenation of oxazolidinones and their conversion to allyl amines 3a-e, key precursors for potential HIV protease inhibitors is described.