220058-27-5

Upstream product

• 108-24-7 acetic anhydride 
• 220058-21-9 (R)-1-[(2S)-1-benzylpyrrolidin-2-yl](phenyl)methanol 
• 220058-24-2 (2S,3R)-1-benzyl-3-hydroxy-2-phenylpiperidine 
• 74936-94-0 (S)-(-)-5-benzoyl-2-pyrrolidinone 
• 195138-76-2 (S)-5-Oxo-pyrrolidine-2-carboxylic acid methoxy-methyl-amide 
• 4931-66-2 methyl (S)-pyroglutamate 
• 100-58-3 phenylmagnesium bromide 
• 100-39-0 benzyl bromide 

Downstream Products

• 250589-62-9 (2S,3R)-3-Acetoxy-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 220058-24-2 (2S,3R)-1-benzyl-3-hydroxy-2-phenylpiperidine 
• 1189765-57-8 C₁₃H₁₇NO₂ 
• 250589-64-1 (2S,3S)-1-benzyl-3-hydroxy-2-phenylpiperidin 
• 250589-63-0 (2S,3R)-tert-butyl 3-hydroxy-2-phenylpiperidine-1-carboxylic acid 
• 191669-62-2 (S)-tert-butyl 3-carbonyl-2-phenylpiperidine-1-carboxylic acid 
• 271588-24-0 (2S)-1-benzyl-2-phenylpiperidin-3-one 
• 148701-46-6 cis-(3S)-hydroxy-(2S)-phenylpiperidine 
• 159249-47-5 tert-butyl (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylate 

Relevant academic research and scientific papers

Enantioselective ring expansion of prolinols: An efficient and short synthesis of 2-phenylpiperidin-3-ol derivatives and 3-hydroxypipecolic acids

A very short route to 2-phenylpiperidin-3-ol derivatives and 3-hydroxypipecolic acids is described. The approach uses two key steps: a one-pot reduction/Grignard addition sequence applied to alkyl proline esters and a ring expansion applied to the corresp

Enantioselective synthesis of 2,3-disubstituted piperidines from (S)- methylpyroglutamate

N-methoxy-N-methylamide derived from (S)-methylpyroglutamate was prepared in good yield and allowed the addition of Grignard reagents. Erythro (2S)-1-benzyl-2-hydroxybenzyl pyrrolidine obtained by this way was converted into (2S,3R)-1-benzyl-3-hydroxy-2-phenylpiperidine and its chloro analog.