220073-77-8

Basic information

• Product Name: Piperidine, 1-acetyl-2-propyl-, (2S)- (9CI)
• Synonyms: Piperidine, 1-acetyl-2-propyl-, (2S)- (9CI)
• CAS NO: 220073-77-8
• Molecular Formula: C10H19NO
• Molecular Weight: 169.26396
• Product Categories: ACETYLGROUP
• Mol File: 220073-77-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperidine, 1-acetyl-2-propyl-, (2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-acetyl-2-propyl-, (2S)- (9CI)(220073-77-8)
• EPA Substance Registry System: Piperidine, 1-acetyl-2-propyl-, (2S)- (9CI)(220073-77-8)

Safety Data

• Hazardous Substances Data: 220073-77-8(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 3238-60-6 rac-coniine 
• 1407999-18-1 N-(8-hydroxyoctan-4-yl)acetamide 
• 1407999-19-2 5-acetamidooctyl-4-methylbenzene sulfonate 
• 1407999-17-0 8-(benzyloxy)oct-5-yn-4-amine 
• 1407998-97-3 2-[8-(benzyloxy)oct-5-yn-4-yl]isoindoline-1,3-dione 
• 1258153-61-5 8-(benzyloxy)oct-5-yn-4-ol 
• 401789-15-9 (3S,4R)-3-(phenylsulfonyl)-4-[(S)-(p-tolylsulfinyl)amino]hept-1-ene 
• 401789-18-2 N-allyl-N-(2-benzenesulfonyl-1-propyl-but-3-enyl)-acetamide 
• 401789-17-1 (3S,4R)-N-(2-propenyl)-3-(phenylsulfonyl)hept-1-en-4-amine 
• 401789-19-3 (2R,3S)-1-acetyl-3-(phenylsulfonyl)-2-propyl-1,2,3,6-tetrahydropyridine 
• 401789-16-0 (3S,4R)-3-(phenylsulfonyl)hept-1-en-4-amine 
• 401789-20-6 (2R,3S)-1-acetyl-3-(phenylsulfonyl)-2-propylpiperidine 
• 64-19-7 acetic acid 

Relevant articles and documents

Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline

Oxidoreductases from Streptomyces sp. GF3546 [3546-IRED], Bacillus cereus BAG3X2 (BcIRED) and Nocardiopsis halophila (NhIRED) each reduce prochiral 2-methylpyrroline (2MPN) to (S)-2-methylpyrrolidine with >95 % ee and also a number of other imine substrates with good selectivity. Structures of BcIRED and NhIRED have helped to identify conserved active site residues within this subgroup of imine reductases that have S selectivity towards 2MPN, including a tyrosine residue that has a possible role in catalysis and superimposes with an aspartate in related enzymes that display R selectivity towards the same substrate. Mutation of this tyrosine residue - Tyr169 - in 3546-IRED to Phe resulted in a mutant of negligible activity. The data together provide structural evidence for the location and significance of the Tyr residue in this group of imine reductases, and permit a comparison of the active sites of enzymes that reduce 2MPN with either R or S selectivity.

Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process

The non-enzymatic kinetic resolution of diversely substituted primary propargylic amines is reported featuring a highly selective acetyl transfer using (1S,2S)-1 in conjunction with AliquatTM 336, affording the corresponding enantio-enriched N-

Asymmetric syntheses of N-acetyl-(R)-coniine and N-Boc-(2R,6R)-solenopsin A via ring-closing metathesis

Asymmetric syntheses of piperidine alkaloids N-acetyl-(R)-coniine and (2R,6R)-trans-solenopsin were achieved utilizing stereoselective additions of allylphenylsulfone to chiral alkyl-N-sulfinylimines and ring-closing olefin metathesis.