220081-35-6

Basic information

• Product Name: (R)-2-Methyl-4-oxo-4-((S)-1-trityl-pyrrolidin-2-yl)-butyric acid methyl ester
• CAS NO: 220081-35-6
• Molecular Weight: 441.57
• Mol File: 220081-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-Methyl-4-oxo-4-((S)-1-trityl-pyrrolidin-2-yl)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Methyl-4-oxo-4-((S)-1-trityl-pyrrolidin-2-yl)-butyric acid methyl ester(220081-35-6)
• EPA Substance Registry System: (R)-2-Methyl-4-oxo-4-((S)-1-trityl-pyrrolidin-2-yl)-butyric acid methyl ester(220081-35-6)

Safety Data

• Hazardous Substances Data: 220081-35-6(Hazardous Substances Data)

Upstream product

• 115724-80-6 (R)-2-trifluoromethanesulfonyloxy-propionic acid methyl ester 
• 220081-16-3 3-Oxo-3-((S)-1-trityl-pyrrolidin-2-yl)-propionic acid allyl ester 
• 1911-74-6 (S)-tritylproline 

Relevant articles and documents

A stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres

A simple, stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres has been developed. N-Tritylated ketomethylene dipeptide isosteres, prepared from N-tritylated amino acids, are converted to their Z- TMS enol ethers and fluorinated with Selectfluor. There is cooperative stereocontrol between the N-tritylamine group and the alkyl group at C-2. The method is short (six steps), diastereoselective (85 → 95%), and enantioselective (>95%).