220101-42-8

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 41995-04-4 4-chloro-2-nitro-benzoyl chloride 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 611199-33-8 diethyl 2-(4-chloro-2-nitrobenzoyl)malonate 

Downstream Products

• 220101-47-3 2-(4-Chloro-2-nitro-phenyl)-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 350238-05-0 {2-Benzyloxycarbonylamino-2-[5-chloro-2-(2-phenylcarbamoyl-acetyl)-phenylcarbamoyl]-acetylamino}-acetic acid benzyl ester 
• 350238-02-7 {2-Benzyloxy-1-[5-chloro-2-(2-phenylcarbamoyl-acetyl)-phenylcarbamoyl]-ethyl}-carbamic acid benzyl ester 
• 350238-03-8 {[5-Chloro-2-(2-phenylcarbamoyl-acetyl)-phenylcarbamoyl]-phenylcarbamoyl-methyl}-carbamic acid benzyl ester 
• 350238-06-1 3-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-succinamic acid methyl ester 
• 350238-04-9 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester 
• 350238-07-2 3-[2-(2-azido-acetylamino)-4-chloro-phenyl]-3-oxo-N-phenyl-propionamide 
• 350238-01-6 3-[2-(2-bromo-acetylamino)-4-chloro-phenyl]-3-oxo-N-phenyl-propionamide 
• 350237-98-8 3-(2-amino-4-chloro-phenyl)-3-oxo-N-phenyl-propionamide 
• 350237-97-7 3-(4-chloro-2-nitro-phenyl)-3-oxo-N-phenyl-propionamide 

Relevant academic research and scientific papers

Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues

A variety of 4-substituted quinolin-2(1H)-ones were prepared and evaluated for N-methyl-D-aspartate (NMDA) receptor binding site activity and their abilities to inhibit neurotoxicity. The 4-(2-carbethoxyethanamino)- 7-chloro-3-nitroquinolin-2(1H)-one (9b)

Efficient synthesis of novel benzo-[e]-[1,4]-diazepine derivatives

Following two efficient synthetic routes a novel series of benzo-[e]-[1,4]-diazepine derivatives, bearing an unusual Z exo-methylencarbamoyl side chain at the C-5 position, have been prepared to identify new antagonists of the glycine binding site associa

Dibenzo[1,6]naphthyridindiones as modified quinolone antibacterials

A series of dibenzo[1,6]naphthyridindiones, synthesized as modified quinolones, in which the usual carboxylic group was replaced by a heterocyclic amide function, was evaluated for antibacterial activity. None of the target compounds showed any significant antibacterial activity. Semiempirical molecular orbital AM1 calculations allowed us to hypothesize that the lack of activity could depend on amide tautomeric equilibrium.