220101-47-3Relevant academic research and scientific papers
Dibenzo[1,6]naphthyridindiones as modified quinolone antibacterials
Cecchetti, Violetta,Fravolini, Arnaldo,Sabatini, Stefano,Tabarrini, Oriana,Xin, Tao
, p. 899 - 903 (2007/10/03)
A series of dibenzo[1,6]naphthyridindiones, synthesized as modified quinolones, in which the usual carboxylic group was replaced by a heterocyclic amide function, was evaluated for antibacterial activity. None of the target compounds showed any significant antibacterial activity. Semiempirical molecular orbital AM1 calculations allowed us to hypothesize that the lack of activity could depend on amide tautomeric equilibrium.
