220114-32-9 Usage
Uses
Used in Asymmetric Hydrogenation:
Dichloro(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) is used as a catalyst for the asymmetric hydrogenation of amino ketones. The application reason is its ability to selectively catalyze the hydrogenation process, leading to the formation of chiral products with high enantioselectivity and yield.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Dichloro(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) is used as a catalyst for the synthesis of chiral pharmaceutical compounds. The application reason is its ability to facilitate the production of enantiomerically pure drugs, which is crucial for ensuring the desired biological activity and minimizing potential side effects.
Used in Chemical Synthesis:
Dichloro(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) is used as a catalyst in the synthesis of various chiral compounds, such as chiral alcohols, amines, and other organic molecules. The application reason is its high catalytic efficiency and selectivity, which allows for the production of chiral products with excellent enantiomeric excess and diastereoselectivity.
Reaction
Highly active catalyst for hydrogenation of simple ketones giving high enantioselectivity when sterically unsymmetrical ketones such as acetophenone, heteroaryl ketones, benzophenones, cyclopropyl ketones, and cyclohexyl ketones are substrates. Ee's are enhanced with XylBINAP relative to BINAP. The otherwise poorly bonded ketone is held in the transition state by hydrogen bonding to the protic bidentate amine.
Carbonyl groups are selectively reduced even when olefins exist in the same molecule.
In the presence of strong base, and catalyst, simple ketones, having substituents at the α-position, may be induced to undergo dynamic kinectic resolution during their hydrogenation to produce two chiral carbon centers in high yield.
Check Digit Verification of cas no
The CAS Registry Mumber 220114-32-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,1,1 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 220114-32:
(8*2)+(7*2)+(6*0)+(5*1)+(4*1)+(3*4)+(2*3)+(1*2)=59
59 % 10 = 9
So 220114-32-9 is a valid CAS Registry Number.
220114-32-9Relevant academic research and scientific papers
RUTHENIUM COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE ALCOHOL COMPOUND
-
Page/Page column 24, (2011/11/13)
The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having ruthenacycle structure, a catalyst for asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol using the ruthenium complex.
