220119-24-4

Upstream product

• 591-17-3 meta-bromotoluene 
• 3406-02-8 bis(phenylsulfonyl)methane 
• 620-23-5 m-tolyl aldehyde 
• 108-98-5 thiophenol 

Downstream Products

• 220119-26-6 15-deoxy-16-m-tolyl-17,18,19,20-tetranorisocarbacyclin methylester 
• 220119-25-5 5-[(3aS,5R,6R,6aS)-6-((E)-4,4-Bis-benzenesulfonyl-4-m-tolyl-but-1-enyl)-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Diverse functionalization of aryl halides mediated by bis(phenylsulfonyl)methane

A palladium-catalyzed coupling reaction of bis(phenylsulfonyl)methane and aryl halides was developed. A variety of bis(phenylsulfonyl)methyl arenes were prepared in good yields. The transformations of bis(phenylsulfonyl)methyl to methyl, trideuteriomethyl, ethyl, carboxyl, and other functional groups were demonstrated. The results provided a new approach to diverse functionalization of aryl halides.

15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: A simple TIC derivative with potent anti-apoptotic activity for neuronal cells

Biologically remarkable 15-deoxy-TIC has been realised by the removal of the C(15) chiral centre in 15R-TIC, a stable ligand for a CNS-type prostacyclin receptor (IP2); this deoxy derivative exhibits ten-fold higher affinity and selectivity tha