220119-25-5Relevant academic research and scientific papers
15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: A simple TIC derivative with potent anti-apoptotic activity for neuronal cells
Suzuki, Masaaki,Kato, Koichi,Watanabe, Yumiko,Satoh, Takumi,Matsumura, Kiyoshi,Watanabe, Yasuyoshi,Noyori, Ryoji
, p. 307 - 308 (2007/10/03)
Biologically remarkable 15-deoxy-TIC has been realised by the removal of the C(15) chiral centre in 15R-TIC, a stable ligand for a CNS-type prostacyclin receptor (IP2); this deoxy derivative exhibits ten-fold higher affinity and selectivity tha
