220122-53-2Relevant academic research and scientific papers
Identification of an Opioid κ Receptor Subtype-Selective N-Substituent for (+) - (3R,4K) -Dimethyl-4- (3-hy droxyphenyl)piperidine
Thomas, James B.,Fall, Michael J.,Cooper, Julie B.,Rothman, Richard B.,Wayne Mascarella,Xu, Heng,Partilla, John S.,Dersch, Christina M.,McCullough, Karen B.,Cantrell, Buddy E.,Zimmerman, Dennis M.,Ivy Carroll
, p. 5188 - 5197 (2007/10/03)
A three-component library of compounds was prepared in parallel using multiple simultaneous solution-phase synthetic methodology. The compounds were biased toward opioid receptor antagonist activity by incorporating (+)-(3,4)-dimethyl-4-(3-hydroxyphenyl)p
