220126-32-9Relevant academic research and scientific papers
Varying the ratio of formic acid to triethylamine impacts on asymmetric transfer hydrogenation of ketones
Zhou, Xiaowei,Wu, Xiaofeng,Yang, Bolun,Xiao, Jianliang
, p. 133 - 140 (2012)
Asymmetric transfer hydrogenation (ATH) is frequently carried out in the azeotropic mixture of formic acid (F) and triethylamine (T), where the F/T molar ratio is 2.5. This study shows that the F/T ratio affects both the reduction rate and enantioselectivity, with the optimum ratio being 0.2 in the ATH of ketones with the Ru-TsDPEN catalyst. Under such conditions, a range of substrates have been reduced, affording high yields and good to excellent enantioselectivities. In comparison with the common azeotropic F-T system, the reduction is faster. This protocol improves both the classic azeotropic and the aqueous-formate system when using water-insoluble ketones.
