220130-49-4Relevant articles and documents
Mechanochemical lignin-mediated strecker reaction
Dabral, Saumya,Turberg, Mathias,Wanninger, Andrea,Bolm, Carsten,Hernández, José G.
, (2017/02/15)
A mechanochemical Strecker reaction involving a wide range of aldehydes (aromatic, heteroaromatic and aliphatic), amines, and KCN afforded a library of α-aminonitriles upon mechanical activation. This multicomponent process was efficiently activated by li
Lanthanide coordination polymer constructed from 2,2′-bipyridyl-4,4′-dicarboxylic acid: Structure, catalysis and fluorescence
Wang, Shengyan,Xu, Jianing,Zheng, Jifu,Chen, Xiaodong,Shan, Liang,Gao, Lijuan,Wang, Li,Yu, Miao,Fan, Yong
, p. 81 - 86 (2015/09/15)
Two new isostructural lanthanide coordination polymers (Ln-CPs) [Ln2(bpdc)3(DMF)2] (Ln = Tb for 1, Eu for 2) with two kinds of one-dimensional channels along the a axis, were synthesized by 2,2′-bipyridyl-4,4′-dicarboxylic acid (H2bpdc) under solvothermal conditions. With exposed Lewis acid Ln3+ centers, 1 as a heterogeneous catalyst shows good catalytic reactivity and selectivity for the Strecker reaction affording medium to excellent conversion yields. Luminescent studies illustrate that 1 and 2 show intensive green and red luminescence triggered by efficient antenna effect of ligands under UV light, respectively. Moreover, 1 exhibits sensitive fluorescent response to Cu2+ in DMF solution.
Iminoheterocycles as γ-secretase modulators
Caldwell, John P.,Bennett, Chad E.,McCracken, Troy M.,Mazzola, Robert D.,Bara, Thomas,Buevich, Alexei,Burnett, Duane A.,Chu, Inhou,Cohen-Williams, Mary,Josein, Hubert,Hyde, Lynn,Lee, Julie,McKittrick, Brian,Song, Lixin,Terracina, Giuseppe,Voigt, Johannes,Zhang, Lili,Zhu, Zhaoning
scheme or table, p. 5380 - 5384 (2010/12/24)
The synthesis of a novel series of iminoheterocycles and their structure-activity relationship (SAR) as modulators of γ-secretase activity will be detailed. Encouraging SAR generated from a monocyclic core led to a structurally unique bicyclic core. Selected compounds exhibit good potency as γ-secretase modulators, excellent rat pharmacokinetics, and lowering of Aβ42 levels in various in vivo models.
