220131-30-6

Upstream product

• 456-49-5 1-fluoro-3-methoxybenzene 
• 598-21-0 2-Bromoacetyl bromide 
• 98619-07-9 1-(2-fluoro-4-hydroxyphenyl)ethanone 

Downstream Products

• 1290181-23-5 3-(2-fluoro-4-hydroxyphenyl)-3-oxopropanenitrile 
• 1260099-55-5 2-(4-benzoyl-piperazin-1-yl)-1-(2-fluoro-4-hydroxy-phenyl)-ethanone 
• 220129-63-5 4-(2-Bromoethyl)-3-fluorophenol 
• 252561-67-4 3-fluoro-4-(1,3-thiazol-4-yl)phenol 

Relevant academic research and scientific papers

Methods for preparing vonoprazan fumarate metabolite and deuterated compound thereof

The invention relates to methods for preparing a vonoprazan fumarate metabolite and a deuterated compound thereof, and belongs to the technical field of pharmacy. In the methods, a proper protection group is introduced to protect a phenolic hydroxyl group

PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT

The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent.

SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS

The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.

Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents

This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is NH2; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.

Aminoethylphenoxyacetic acid derivatives and drugs for pain remission and calculi removal promotion in urinary lithiasis

Novel aminoethylphenoxyacetic acid derivatives represented by the general formula: STR1(wherein R 1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R 2 represents a hydrogen atom or a halogen atom; the carbon atom marked with (R) repr