98619-07-9 Usage
Chemical Properties
slightly beige to beige-brown powder
Uses
2'-Fluoro-4'-hydroxyacetophenone is used in used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Preparation
Preparation by reaction of acetyl chloride on 3-fluorophenol with aluminium chloride in refluxing ethylene dichloride.
Check Digit Verification of cas no
The CAS Registry Mumber 98619-07-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,6,1 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 98619-07:
(7*9)+(6*8)+(5*6)+(4*1)+(3*9)+(2*0)+(1*7)=179
179 % 10 = 9
So 98619-07-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FO2/c1-5(10)7-3-2-6(11)4-8(7)9/h2-4,11H,1H3
98619-07-9Relevant articles and documents
A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib
Du, Fangyu,Zhou, Qifan,Shi, Yajie,Yu, Miao,Sun, Wenjiao,Chen, Guoliang
supporting information, p. 576 - 586 (2019/02/01)
A practical synthetic route to regorafenib, in which the target compound was obtained via a 10-step synthesis starting from 2-picolinic acid, 4-chloro-3-(trifluoromethyl)aniline, and 3-fluorophenol, is reported. Crucial to the strategy is the preparation of 4-amino-3-fluorophenol via Fries and Beckman rearrangements using an economical and practical protocol. The main advantages of the route include inexpensive starting materials and an acceptable overall yield. A scale-up experiment was carried out to provide regorafenib with 99.96% purity in 46.5% total yield.
