220139-79-7Relevant articles and documents
Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation
Sakuma, Shogo,Endo, Tsuyoshi,Kanda, Takashi,Nakamura, Hideki,Yamasaki, Satomi,Yamakawa, Tomio
scheme or table, p. 240 - 244 (2011/02/27)
We successfully synthesized a novel peroxisome proliferator-activated receptor (PPAR)δ selective agonist, namely, compound 20, with a characteristic benzisoxazole ring. Compound 20 exhibited potent human PPARδ transactivation activity and high δ selectivity. Further, it stimulated differentiation of primary oligodendrocyte precursor cells in vitro, indicating that it may be an effective drug in the treatment of demyelinating disorders such as multiple sclerosis.
