22014-73-9

Basic information

• Product Name: Thiourea, N-butyl-N'-(2,4-dichlorophenyl)-
• CAS NO: 22014-73-9
• Molecular Formula: C11H14Cl2N2S
• Molecular Weight: 277.218
• Mol File: 22014-73-9.mol

Chemical Properties

• CAS DataBase Reference: Thiourea, N-butyl-N'-(2,4-dichlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-butyl-N'-(2,4-dichlorophenyl)-(22014-73-9)
• EPA Substance Registry System: Thiourea, N-butyl-N'-(2,4-dichlorophenyl)-(22014-73-9)

Safety Data

• Hazardous Substances Data: 22014-73-9(Hazardous Substances Data)

Upstream product

• 109-73-9 N-butylamine 
• 6590-96-1 2, 4-dichlorophenyl isothiocyanate 

Relevant articles and documents

Facile synthesis of phthalidyl fused spiro thiohydantoins through silica sulfuric acid induced oxidative rearrangement of ninhydrin adducts of thioureas

A one-pot three-component sequential synthetic protocol produces structurally and biologically important phthalidyl fused spiro N,N′-disubstituted thiohydantoins from readily available aromatic isothiocyanates, primary amines and ninhydrin. In this three-step synthesis while the initial two steps are catalyst-free, in the final step silica sulfuric acid (SSA) induces an oxidative rearrangement in [3.3.0]-bicyclic 1,2-diol adducts of ninhydrin and thioureas under solvent-free condition to generate the final products spiro-fused thiohydantoins. The adequate acidity of SSA in cooperation with moderate oxidizing property promotes a facile oxidative rearrangement in 1,2-diol intermediates to produce the spiro-fused thiohydantoins with diverse functionalities. Easy recyclability of SSA, good to excellent yield of the products, wider substrate scope, shorter reaction time, solvent-free two steps out of three and high atom economy make this method attractive and practicable.