220166-97-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 220166-92-7 diethyl [(Z)-1,1-difluoro-5-hydroxy-2-pentenyl]phosphonate 
• 220166-88-1 diethyl [(Z)-1,1-difluoro-5-(tetrahydro-2H-2-pyranyloxy)-2-pentenyl]phosphonate 

Relevant academic research and scientific papers

Synthesis of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase

A series of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids, (E)-2a,b and (Z)-2a,b, as well as the related methano analogues (±)-3a,b and (±)-4a,b were prepared for evaluation of their PNP inhibitory activities. The cyclopopane ring and the hypox