Synthesis of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase

DOI: 10.1016/S0968-0896(98)80023-0

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2495 - 2505 (1998)

Update date:2022-07-29

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Authors:

Yokomatsu, Tsutomu

Abe, Hiroshi

Sato, Mutsumi

Suemune, Kenji

Kihara, Taro

Soeda, Shinji

Shimeno, Hiroshi

Shibuya, Shiroshi

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Article abstract of DOI:10.1016/S0968-0896(98)80023-0

A series of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids, (E)-2a,b and (Z)-2a,b, as well as the related methano analogues (±)-3a,b and (±)-4a,b were prepared for evaluation of their PNP inhibitory activities. The cyclopopane ring and the hypox

Full text of DOI:10.1016/S0968-0896(98)80023-0

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