Bioorganic and Medicinal Chemistry p. 2495 - 2505 (1998)
Update date:2022-07-29
Topics:
Yokomatsu, Tsutomu
Abe, Hiroshi
Sato, Mutsumi
Suemune, Kenji
Kihara, Taro
Soeda, Shinji
Shimeno, Hiroshi
Shibuya, Shiroshi
A series of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids, (E)-2a,b and (Z)-2a,b, as well as the related methano analogues (±)-3a,b and (±)-4a,b were prepared for evaluation of their PNP inhibitory activities. The cyclopopane ring and the hypox
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