220169-75-5Relevant academic research and scientific papers
Enantioselective synthesis of 1-methoxy- and 1-deoxy-2′-methyl- Δ8-tetrahydrocannabinols: New selective ligands for the CB 2 receptor
Huffman, John W.,Bushell, Simon M.,Joshi, Sudhir N.,Wiley, Jenny L.,Martin, Billy R.
, p. 247 - 262 (2007/10/03)
Two new series of cannabinoids were prepared and their affinities for the CB1 and CB2 receptors were determined. These series are the (2′R)- and (2′S)-1-methoxy- and 1-deoxy-3-(2′-methylalkyl) -Δ8-tetrahydrocannabinols, wi
Synthesis and pharmacology of the isomeric methylheptyl-Δ8-tetrahydrocannabinols
Huffman, John W.,Liddle, John,Duncan Jr., Sammy G.,Yu, Shu,Martin, Billy R.,Wiley, Jenny L.
, p. 2383 - 2396 (2007/10/03)
The synthesis of the 3-heptyl, and the eleven isomeric 3-methylheptyl-Δ8-tetrahydrocannabinols (3-7, R and S methyl epimers, and 8) has been carried out. The synthetic approach entailed the synthesis of substituted resorcinols, which were subjected to acid catalyzed condensation with trans-para-menthadienol to provide the Δ8-THC analogue. The 1'-, 2'- and 3'-methylheptyl analogues (3-5) are considerably more potent than Δ8-THC. The 4'-, 5'- and 6'-methylheptyl isomers (6-8) are approximately equal in potency to Δ8-THC. Copyright (C) 1998 Elsevier Science Ltd.
