75018-77-8

Upstream product

• 122333-94-2 3-(3,5-dimethoxyphenyl)-2-methylpropanoic acid 
• 187084-19-1 N-((1S)-1-phenylethyl)-(2R)-3-(3,5-dimethoxyphenyl)-2-methylpropanamide 
• 187084-20-4 N-((1S)-1-phenylethyl)-(2S)-3-(3,5-dimethoxyphenyl)-2-methylpropanamide 
• 187083-96-1 (R)-3-(3,5-dimethoxyphenyl)-2-methylpropionic acid 
• 187084-06-6 (S)-3-(3,5-Dimethoxy-phenyl)-2-methyl-propionic acid 
• 122333-93-1 3-(3,5-dimethoxyphenyl)-2-methylpropenoic acid 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 98-59-9 p-toluenesulfonyl chloride 
• 187084-05-5 (S)-2-methyl-3-(3,5-dimethoxyphenyl)-1-propanol 

Downstream Products

• 187140-42-7 (R)-1-(3,5-dimethoxyphenyl)-2-methylpentane 
• 220169-75-5 (R)-1-(3,5,-dimethoxyphenyl)-2-methylheptane 

Relevant academic research and scientific papers

Side chain methyl analogues of Δ8-THC

The synthesis of both side chain epimers of 1'- (4), 2'- (5), 3'-methyl- (6) and 4'-methyl-Δ8-tetrahydrocannobinol (7) has been carried out. The synthetic approach entailed the acid catalyzed condensation of the appropriate substituted resorcinol with menthadienol to provide the Δ8-THC analogue. Both isomers of 1'- (4) and 2'-Δ8-THC (5) were more potent than Δ8-THC, both in vitro and in vivo. The 3'-methyl isomers (6) were approximately equal in potency to Δ8-THC, and 4'-methyl-Δ8-THC was less potent. There was relatively little difference in potency between the epimers of 4, 5, and 6.